sestrin2

نتایج جستجو برای: sestrin2

تعداد نتایج: 129 فیلتر نتایج به سال:

The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases

Journal: :Aging and disease 2020

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Metastatic Melanoma Cells Rely on Sestrin2 to Acquire Anoikis Resistance via Detoxifying Intracellular ROS

Journal: :Journal of Investigative Dermatology 2020

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Sestrin2 prevents age‐related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

Journal: :The FASEB Journal 2017

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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Journal: :Cell reports 2014

Lynne Chantranupong Rachel L Wolfson Jose M Orozco Robert A Saxton Sonia M Scaria Liron Bar-Peled Eric Spooner Marta Isasa Steven P Gygi David M Sabatini

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound to RagC or RagD) in order to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. GATOR2 is a complex of unknown function th...

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