نتایج جستجو برای: serum metabolites
تعداد نتایج: 359947 فیلتر نتایج به سال:
introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...
BACKGROUND Untargeted metabolomics was used in case-control studies of adenocarcinoma (ADC) lung cancer to develop and test metabolite classifiers in serum and plasma as potential biomarkers for diagnosing lung cancer. METHODS Serum and plasma were collected and used in two independent case-control studies (ADC1 and ADC2). Controls were frequency matched for gender, age, and smoking history. ...
A liquid-liquid extraction technique and HPLC-DAD method using a C18 column, 5μm (150x4.6mm i.d.) were developed for toxicological drug screening. home-made “N-acetylparoxetine” is used as internal standard. local UV spectra library of over 130 drugs some their metabolites was created. This covers the main therapeutic classes involved in intoxication cases. The procedure successfully applied to...
BACKGROUND Comprehensive identification of human drug metabolites in first-in-man studies is crucial to avoid delays in later stages of drug development. We developed an efficient workflow for systematic identification of human metabolites in plasma or serum that combines metabolite prediction, high-resolution accurate mass LC-MS and MS vendor independent data processing. Retrospective evaluati...
AIMS The tryptophan metabolites 3-hydroxykynurenine (3-HK) and 3-hydroxyanthranilic acid (3-HAA) inhibit the liver mitochondrial low Km aldehyde dehydrogenase and possess alcohol-aversive and immunosuppressant properties. As the disulfiram (DS) metabolite carbon disulphide activates enzymes forming 3-HK and 3-HAA, we investigated if repeated disulfiram treatment increases the hepatic and serum ...
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,0...
The absolute quantification of blood plasma metabolites by proton NMR spectroscopy is complicated by the presence of a baseline and broad resonances originating from serum macromolecules and lipoproteins. A method for spectral simplification of proton NMR spectra of blood plasma is presented. Serum macromolecules and metabolites are completely separated by utilizing the large difference in tran...
in order to determine the involvement of nitric oxide in the pathogenesis of coccidiosis induced by eimeria, 30 chickens were challenged with mixed sporulated oocysts of four species of eimeria (e. acervulina, e. maxima, e. necatrix, and e. tenella) at 26 days of age. there was an increasing of oocyst shedding in the infected birds at 6, 10 and 14 days post-infection. histopathological examinat...
BACKGROUND Increasing scientific evidence suggests that exposure to phthalates during pregnancy may be associated with an elevated risk of adverse reproductive outcomes such as preterm birth. Maternal endocrine disruption across pregnancy may be one pathway mediating some of these relationships. We investigated whether urinary phthalate metabolites were associated with maternal serum thyroid (f...
We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and recombinant inbred strains. We find that metabolites exhibit a wide range of variation, as has been previously observed with metabolites in blood ser...
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