background: azadirachta indica is a tree with most of the parts having various medicinal values. it is however popular because of its high potencies, as antimalarial and anti-fertility agents, which the locals still exploit. objective: we investigated the effect of the methanol leaf extract on the serum levels of the pituitary-gonad hormones and the histo-morphology of the ovary and uterus of a...

Thyroid hormone action is mediated by the thyroid hormone receptors TRα1 and TRβ. Defects in TRβ lead to RTH (resistance to thyroid hormone) β, a syndrome characterized by high levels of thyroid hormone and non-suppressed TSH (thyroid-stimulating hormone). However, a correct diagnosis of RTHβ patients is difficult as the clinical picture varies. A biochemical serum marker indicative of defects ...

introduction regular intake of n-3 fatty acids of marine origin have desirable effects on serum lipoproteins and reduce coronary vascular disease (cvd). n-3 fatty acid supplementation decreased serum triglyceride concentrations in studies in which most of the subjects were male. the effects of n-3 fatty acids supplementation in fat women especially postmenopausal fat women have received little ...

The gonadotropin-ovary axis of patients with anorexia nervosa was assessed with the aim of distinguishing between an intrinsically hypophysial deficiency and pituitary malfunction secondary to hypothalamic impairment. The most consistent endocrine abnormality was low serum luteinizing and follicle stimulating hormone (LH and FSH) levels associated with depressed serum estradiol levels. Gonadotr...

An adult patient presenting in summertime with sarcoidosis and demonstrating raised levels of serum calcium and 1,25-dihydroxycholecalciferol was observed to have a serum immuno-reactive parathyroid hormone concentration in the mid-normal range. Renal function was normal. Corticosteroid administration quickly depressed serum calcium and 1,25-dihydroxycholecalciferol into the normal range; serum...

In a case of acromegalic gigantism with hyperprolactinemia is reported, the basal serum growth hormone (GH) levels ranged from 1.2 to 1.9 ng/ml. Serum GH response to either insulin-induced hypoglycemia or GH-releasing hormone was blunted. Frequent blood sampling showed non-pulsatile GH secretion. Serum prolactin and insulin-like growth factor-I (IGF-I) levels were elevated. After unsuccessful s...

Normal somatic growth requires that both the thyroid hormone axis and GH axis be intact. Thyroid hormone stimulates GH secretion, and many thyroid hormone actions on the insulin-like growth factor (IGF) system can be explained by this mechanism. We have previously described distinct changes in IGF binding protein (IGFBP) expression in experimental hypothyroidism in the rat; these changes could ...

PURPOSE To determine the sex hormone levels in the serum and aqueous humor in patients with age-related cataract and the corresponding hormone receptors in cataract lens epithelial cells (LECs). SETTING Research Laboratory, International Intraocular Implant Training Center, Tianjin Medical University, Tianjin, China. METHODS Serum and aqueous humor were drawn from patients with cataract and...

Endocrine disorders are common in adults with epilepsy on antiepileptic drugs (AEDs). This study aimed to evaluate endocrine function, lipid metabolism and growth in patients with childhoodor adolescence-onset epilepsy. Altogether 148 patients with epilepsy on carbamazepine (CBZ), oxcarbazepine (OXC), valproate (VPA) or lamotrigine monotherapy during pubertal maturation and 124 healthy controls...