OBJECTIVE Non-functioning pituitary adenomas (NFPAs) are characterised by the lack of symptoms of hormone hypersecretory syndromes but in vitro studies have demonstrated that tumour cells may stain for gonadotrophins and/or their alpha- or beta-subunits. In this study, we aimed to examine the pattern of secretion of LH and FSH from a series of pituitary adenomas cultured in vitro and where data...

BACKGROUND Serum FSH elevations and decreases in inhibin B have been consistently demonstrated in the early follicular phase of cycles in women of advanced reproductive age. However, secretory products of the dominant follicle (estradiol and inhibin A) in the serum of older ovulatory women are maintained at levels similar to those of their younger counterparts. The goal of this investigation wa...

Synthetic luteinizing hormone-releasing hormone (LH-RH) was given in doses of 11-100 Vg to normal men. Doses of 50 and 100 t±g caused a twoto ten-fold rise in serum LH in all subjects, but in only 40% was the serum follicle-stimulating hormone (FSH) elevated. A significantly higher LH response to LHRH was seen in subjects in whom a rise in serum FSH could be detected. Although there was a wide ...

OBJECTIVE The aim of the present study was to investigate the relationship between ovarian follicle count and volume on ultrasonography and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin in women with the polycystic ovary syndrome (PCOS). METHODS A total of 118 Korean women aged 18-35 years who were newly diagnosed with PCOS at a university hosp...

Prepubertal (14 days old) and mature (10 to 12 months old) male rats were hemicastrated and killed at selected intervals during a 12-week period to compare the effect of age on acute and chronic pituitary and testicular responses to hemicastration. Testis weight was increased (P less than 0.05) in hemicastrated (HC) prepubertal rats but not in mature rats compared with intact controls. After su...

The purification and action sites of a follicle stimulating hormone (FSH) inhibitor obtained from bovine follicular fluid were examined. Bovine follicular fluid was salted out with ammonium sulfate as a concentration of 14.5 to 18.5%, and the salted out fraction was separated into two peaks by Sephadex G-200 column chromatography. The second peak, detectable as a single band by polyacrylamide g...

Background: Female age and basal FSH level are independently associated with IVF outcome. They are both related to the same phenomenon, namely ovarian reserve. Objective: To evaluate the effective role of serum FSH concentration at the start of treatment cycle on ART outcome. Materials and Methods: A total of 207 women undergoing IVF and ICSI cycles were included in this study. Basal FSH concen...

Wistar-Imamichi male rats were slowly infused with synthetic TRH (T), LRH(L) and T +L in combination for of 1, 3, 24, 48 and 72hr. Doses of the releasing hormones were 1ƒÊg/hr. For each duration of infusioi,pituitary and serum TSH, LH and FSH concentrations were radioimmunoassayed. , When T is infused, the pituitary TSH concentration increases at 72hr. When L is infused, it increases at 48hr bu...

Because there is an unexpected action of testosterone (T) to increase follicle-stimulating hormone (FSH) production in the absence of gonadotropin-releasing hormone (GnRH) in the rat, the effects of T treatment on circulating FSH were studied in men with GnRH deficiency. FSH immunoreactivity was identified in serum using a sensitive two-site immunoassay in each of five untreated GnRH-deficient ...