there are many reports for involvement of atp-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. this study examined the effect of single doses of k+ channel openers diazoxide, minoxidil and k+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. blood samples were obtained 60 minutes after drug treatment and serum...

Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration. Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Gl...

The aim of this study is to determine the serum copper (Cu) concentration found in Iranian Raeini cashmere goats in different seasonal and climatic conditions. Twenty four male (6 to 18 months old) and 48 female (6 to 18 and 18 to 30 months old) Raeini goats were selected from the station, rural, and nomadic flocks. The average Cu concentrations among the male and female goats were 0.5 ± 0.04 a...

In circumstances such as in vitro fertilization (IVF) or in patients with luteal phase defect, one needs to ensure the establishment of pregnancy as soon as possible. At the same time, a question arises: How can a physician make sure that the β-hCG is of an endogenous source and not the residue of the prescribed drugs (hCG)? In this article we have studied the elimination time of 1M inject...

An algorithm is suggested for interpretation of serum ethanol concentrations under legal statutes that specify whole-blood alcohol concentrations. The algorithm uses the distribution of individual serum:whole-blood alcohol concentration ratios to allow calculations at various levels of confidence that can be related to legal standards of evidence. Serum:whole-blood alcohol concentration ratios ...

Several studies (2-6) of the hydrolysis of proteins by proteolytic eneymes have led to the suggestion that only denatured forms of the substrate are acted on; and that where an equilibrium between native (N) and denatured (D) forms, N $ D, is not spontaneous, the initial action of a protease may be a nonhydrolytic denaturation of native substrate. Green and Neurath (7) have suggested that nativ...

BACKGROUND For patients with schizophrenia clozapine (CLZ) is sometimes co-prescribed with clonazepam (CLNAZ). However, the impact of administration of CLZ along with CLNAZ on the serum concentration of CLZ and its major metabolite N-CLZ in schizophrenia is not well understood. AIM To investigate the effects of CLNAZ co-medication, patient gender, age and CLZ dosage on serum concentration of ...