AIMS To evaluate the efficacy of 50% autologous serum drops against conventional treatment in ocular surface disorders refractory to normal treatments in a prospective randomised crossover trial. METHOD Patients fulfilling ophthalmological and haematological entry criteria were randomised to either 3 months of autologous serum 50% followed by 3 months of their conventional treatment, or 3 mon...

BACKGROUND Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients. METHODS The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the per...

Traveling to high altitudes can expose the eye to reduced ambient cold and low-pressure environments. These conditions can affect the physiology of the eye and may result in ocular problems and visual disturbances. In this paper, ocular disorders related to high altitudes are briefly reviewed. Then, high-altitude ocular disorders are categorized in three parts: those related to dry and cold env...

Background: Immune reactions have been reported to be involved in the destruction of retinal ganglion cells (RGCs) in glaucoma. Objective: To investigate the role of major histocompatibility complex class I-related chain A and B (MICA and MICB) molecules in the pathogenesis of glaucoma. Methods: Aqueous humor and serum samples from 15 glaucoma patients and 45 patients with cataract, undergoing ...

Objective: The present study aims to evaluate coronavirus shedding in the tears of asymptomatic pediatric COVID-19 positive patients. Methods: A prospective interventional that included a total 145 patients hospitalized from 17 th May 2020 16 July Sohag Tropical Hospital. On admission, all them were detected through nasopharyngeal swab. They intimate contact with symptomatic before testing and ...

Human serum-derived and plasma-derived therapies have become increasingly popular in the treatment of ocular surface disorders, with mounting clinical and scientific evidence suggesting good safety and efficacy profiles. These therapies may be considered for various ocular surface conditions, such as dry eye syndrome and persistent epithelial defect, when conservative management does not suffic...

BACKGROUND Blinding trachoma, caused by ocular infection with Chlamydia trachomatis, is targeted for global elimination by 2020. Knowledge of risk factors can help target control interventions. METHODOLOGY/PRINCIPAL FINDINGS As part of a cluster randomised controlled trial, we assessed the baseline prevalence of, and risk factors for, active trachoma and ocular C. trachomatis infection in ran...

Purpose To assess whether a panel of serum pemphigoid autoantibody tests could be used to confirm an immunopathologic diagnosis mucous membrane (MMP) in direct immunofluorescent negative (DIF–) MMP patients. Design Prospective cross-sectional study. Participants Seventy-six patients with multisite 45 matched control participants. Methods Enzyme-linked immunosorbent assays (ELISAs) for BP180 and...

Traditionally it has been difficult or impossible to collect and preserve bacterial samples of especially fastidious bacteria in mixed primary cultures, unless the samples could be transported to a laboratory within approximately 24 h. Therefore, a simple novel method for preserving swab samples until bacterial isolation can be completed in the laboratory was developed and evaluated. Pasteurell...

Background: Idiopathic anterior uveitis is an anterior segment inflammation in which a detailed medical history, general and ocular physical examination is not associated with any defined clinical syndrome. Alterations in immune system parameters have been reported in patients with idiopathic posterior uveitis; however no data on the role of immune system in idiopathic anterior uveitis has yet ...