نتایج جستجو برای: serous tumors
تعداد نتایج: 187057 فیلتر نتایج به سال:
The objective of this study is to investigate hormonal receptor status of MOT (malignant ovarian tumor) and to evaluate its clinical and prognostic significance. Retrospective analysis of the case reports of 284 patients with MOT of different histogenesis, stages I-IV, and immunohistochemical study of paraffin-embedded tissues were performed. Hormonal receptor status of tumors with different mo...
Serous endometrial cancer is a clinically aggressive type of uterine cancer, responsible for a disproportionate incidence of advanced stage disease, recurrences and deaths. Serous endometrial cancers are characterized by alteration of p53, STK15, p16, and HER2. The purpose of this review is to describe the current understanding of the role of the HER-2/neu pathway in the carcinogenesis of serou...
Surface epithelial-stromal tumors are the most common neoplasm of ovary in the reproductive age and beyond. Less than 1% of epithelial ovarian tumors occur before the age of 21 years while 75% of sexcord stromal tumors (Sertoli and Leydig Cell) occur in the third and fourth decades of life. Serous tumors rarely occur in combination with germ cell tumors, sex-cord stromal tumors or granulosa cel...
Activating mutations in KRAS and in one of its downstream mediators, BRAF, have been identified in a variety of human cancers. To determine the role of mutations in BRAF and KRAS in ovarian carcinoma, we analyzed both genes for three common mutations (at codon 599 of BRAF and codons 12 and 13 of KRAS). Mutations in either codon 599 of BRAF or codons 12 and 13 of KRAS occurred in 15 of 22 (68%) ...
Warshaw, A. L, Compton, C. C., Lewandrowski, K., Cardenosa, G. and Mueller, P. R. (1990) Cystic tumors of the pancreas. New clinical, radiologic and pathologic observations in 67 patiems. Annals ofSurgery, 212, 432-445. Within a 12-year period we treated 67 patients (49 women, 18 men; mean age, 61 years) with cystic neoplasms of the pancreas, including 18 serous cystic adenomas, 15 benign mucin...
PURPOSE Low-grade serous ovarian carcinomas (LGSC) are Ras pathway-mutated, TP53 wild-type, and frequently associated with borderline tumors. Patients with LGSCs respond poorly to platinum-based chemotherapy and may benefit from pathway-targeted agents. High-grade serous carcinomas (HGSC) are TP53-mutated and are thought to be rarely associated with borderline tumors. We sought to determine whe...
OBJECTIVE According to the widely accepted pathway, a serous borderline tumor becomes invasive either by progressing into a noninvasive micropapillary tumor or directly through microinvasion. Our objective was to investigate the role of serous borderline tumors and their accompanying extraovarian lesions in pathogenesis of serous ovarian cancer using immunohistochemistry as a tool. MATERIAL A...
Papillary serous low malignant potential (LMP) tumors are characterized by malignant features and metastatic potential yet display a benign clinical course. The role of LMP tumors in the development of invasive epithelial cancer of the ovary is not clearly defined. The aim of this study is to determine the relationships among LMP tumors and invasive ovarian cancers and identify genes contributi...
Ovarian torsion is frequently found in benign cases of non-adhered ovarian tumors. When only a simple cyst without surface nodules detected by preoperative imaging, we tend to classify the tumor as benign. We herein report case that presented and was be high-grade serous carcinoma laparoscopic adnexectomy postmenopausal woman.
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