Infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system. Recurrent ocular shedding can lead to corneal scarring and vision loss making HSV-1 a leading cause of corneal blindness due to an infectious agent. The primary site of HSV-1 latency is sensory neurons within trigeminal ganglia. Periodically, reactivation from latency occur...

Vertebrate hair cells are responsible for the high fidelity encoding of mechanical stimuli into trains of action potentials (spikes) in afferent neurons. Here, we generated a transgenic zebrafish line expressing Channelrhodopsin-2 (ChR2) under the control of the hair-cell specific myo6b promoter, in order to examine the role of the mechanoelectrical transduction (MET) channel in sensory encodin...

After primary infection, varicella-zoster virus (VZV) establishes latency in neurons of the dorsal root and trigeminal ganglia. Many questions concerning the mechanism of VZV pathogenesis remain unanswered, due in part to the strict host tropism and inconsistent availability of human tissue obtained from autopsies and abortions. The recent development of induced pluripotent stem (iPS) cells pro...

introduction: arteriovenous fistulas (avf) make chronic hemodialysis easy, but the complications are unpredictable. ischemic neuropathy due to arterial insufficiency is one of the most important complications of avf. this study was designed to evaluate ischemic neuropathy using electro diagnostic method in the extremity carrying fistula. methods: in this cross-sectional study, 37 hemodialysis p...

Clinical and Electrophysiologic features of Guillan-Barre syndrome in 23 children (1-15 y.old) were prospectively studied during 2 years (Jan. 97 to Jan. 99). These studies were performed at admission in hospital and one month later. 5 patients requied respiratory assistance (G5) and 15 patients were bedridden (G4). 2 patients had chronic GBS and one had recurrence after 6 months. Neurophysiol...

Understanding how populations of neurons encode sensory information is a major goal of systems neuroscience. Attempts to answer this question have focused on responses measured over several hundred milliseconds, a duration much longer than that frequently used by animals to make decisions about the environment. How reliably sensory information is encoded on briefer time scales, and how best to ...

OBJECTIVE To compare sensitivities between 7 principal nerve conduction studies (NCS) for diagnosing carpal tunnel syndrome (CTS). METHOD In 104 CTS and 64 control hands, following "Standard" NCSs were examined simultaneously: (1) Median sensory NCS; (2) segmental wrist-palm sensory NCS; (3) 4th digit latency difference; (4) 1st digit latency difference and (5) palmar mixed nerve latency diff...

In the barrel cortex of rodents, cells respond to a principal whisker (PW) and more weakly to several adjacent whiskers (AWs). Here we show that compared with PW responses, simultaneous wide-field stimulation of the PW and several AWs enhances short-latency responses and suppresses long-latency responses. Multiwhisker enhancement and suppression is first seen at the level of the cortex in layer...