AIM Supplementary functional information can contribute to assess response in targeted therapies. The aim of this study was to evaluate semi-automatic RECIST plus iodine uptake (IU) determination in melanoma metastases under BRAF inhibitor (vemurafenib) therapy using dual-energy computed tomography (DECT). METHODS Nine patients with stage IV melanoma treated with a BRAF inhibitor were include...

The Europa lander is a concept for potential future planetary exploration mission which purpose to characterize the icy shell of and search organics. To achieve this objective, current includes Raman spectrometer, such as RLS instrument, that could be able analyze (sub) surface targets in their solid liquid form. Knowing ice brines are potentially enriched by sulfate chlorides, work seeks evalu...

corneal new vessels can result in significant loss of vision as well as reduce graft survival. Recently, newer treatment modalities have been introduced. however, attempts to meet the challenge of evaluating corneal vessels by quantification are evolving. In vivo evaluations range from computer-aided analysis of colour images to determination of area, diameter and tortuousity of blood vessels o...

Neutrophil extracellular traps (NETs) that are extensive webs of DNA covered with antimicrobial proteins into the extracellular environment during infection or inflammation as a part of their defense arsenal. Image acquisition of fluorescently labeled NETs and subsequent image-based quantification is frequently used to analyze NET formation (NETosis) in response to various stimuli. However, the...