نتایج جستجو برای: selective cox 2 inhibitors

تعداد نتایج: 2821211  

2007
Ting-Ting Hong Jinbao Huang Terrance D. Barrett Benedict R. Lucchesi

This study was designed to determine the effect of inhibitors of COX-1, COX-2 and the nonselective COX inhibitor, naproxen on, coronary vasoactivity and thrombogenicity under baseline and lipopolysaccharide-induced inflammatory conditions. We hypothesize that; endothelial COX-1 is the primary COX isoform in the canine normal coronary artery, which mediates arachidonic acid-induced vasodilatatio...

2010
Johannes W. J. Bijlsma

There is a range of pharmacological options available to the rheumatologist for treating arthritis. Non-selective NSAIDs or Cox-2 selective inhibitors are widely prescribed to reduce inflammation and alleviate pain; however, they must be used with caution in individuals with an increased cardiovascular, renal or gastrointestinal (GI) risk. The potential cardiovascular risks of Cox-2 selective i...

Journal: :Acta dermato-venereologica 2003
Roland Kruse Thomas Ruzicka Markus Grewe

Intolerance reactions due to the ingestion of non-steroidal anti-inflammatory drugs (NSAIDs) are frequent emergencies. It is thought that inhibition of the isoenzyme cyclooxygenase type I (COX-1) is responsible for the common NSAID-associated adverse effects, whereas inhibition of COX-2 is mainly responsible for the therapeutic effects. The goal of our study was to estimate the frequency of int...

Journal: :Molecules 2023

Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role cyclooxygenase-1 (COX-1) inhibition rather neglected. We report that m-terphenylamine derivatives are selective COX-1 inhibitors, able block microglia inflammatory response and elicit a neuroprotective effect. These com...

Journal: :Advanced therapeutics 2023

Abstract The selective inhibition of enzymes that catalyze the conversion arachidonic acid to inflammatory eicosanoids represents a promising approach for cancer therapy. This study, therefore, focuses on incorporation metabolically stable, sterically demanding, and hydrophobic carboranes into existing dual cycloxygenase‐2 (COX‐2)/5‐lipoxygenase (5‐LO) inhibitors are key in biosynthesis eicosan...

Journal: :The Korean Journal of Medicine 2016

Nonsteroidal anti-inflammatory drugs (NSAIDs) act mainly via inhibition of prostaglandins synthesis by inhibition of cyclooxygenase (COX) isoenzymes (COX1 and COX 2). Selective COX-2 inhibitors which are also known as coxibs provide the main therapeutic effects of NSAIDs. Zarghi et al. reported 6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 101) as a novel derivative of...

Journal: :PloS one 2016
Corinna Seliger Christoph R Meier Claudia Becker Susan S Jick Ulrich Bogdahn Peter Hau Michael F Leitzmann

BACKGROUND Selective cyclooxygenase-2 (COX-2) inhibitors are analgesic, antipyretic, and anti-inflammatory drugs. They have been found to inhibit the development of glioma in laboratory investigations. Whether these drugs reduce the risk of glioma incidence in humans is unknown. METHODS We conducted a matched case-control analysis using the U.K.-based Clinical Practice Research Datalink (CPRD...

Journal: :Journal of the American Society of Nephrology : JASN 2002
Masashi Kitahara Frank Eitner Tammo Ostendorf Uta Kunter Ulf Janssen Ralf Westenfeld Katsuyuki Matsui Dontscho Kerjaschki Jürgen Floege

Selective cyclooxygenase-2 (COX-2) inhibitors have anti-inflammatory activity and reduce proteinuria in experimental membranous glomerulonephritis. Antiangiogenic properties of COX-2 inhibitors were recently reported. Whether these properties are relevant to the glomerular healing process in inflammatory glomerular diseases was investigated. For evaluation of the effects of selective COX-2 inhi...

Journal: :Epidemiology 2016
Deirdre P Cronin-Fenton Uffe Heide-Jørgensen Thomas P Ahern Timothy L Lash Peer Christiansen Bent Ejlertsen Henrik T Sørensen

BACKGROUND Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective COX-2 inhibitors may improve outcomes in breast cancer patients. We investigated the association of aspirin, NSAIDs, and use of selective COX-2 inhibitors with breast cancer recurrence. METHODS We identified incident stage I-III Danish breast cancer patients in the Danish Breast Cancer Cooperative Group registry,...

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