Background: The maternal age effect for trisomy is well known. However what is less established is whether certain women are more (or less) prone to segregation errors, independent of age. Trisomy arises primarily through maternal meiosis I chromosome segregation errors however the precise mechanism by which these errors occur is unclear. Current dogma attributes the origin of trisomy to malseg...

Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

Plasmids that contain Saccharomyces cerevisiae TG1-3 telomere repeat sequences (TRS plasmids) segregate efficiently during mitosis. Mutations in histone H4 reduce the efficiency of TRS-mediated plasmid segregation, suggesting that chromatin structure is involved in this process. Sir2, Sir3 and Sir4 are required for the transcriptional repression of genes located at the silent mating type loci (...

The authors examine the research evidence on the effect of residential segregation on health, identify research gaps, and propose new research directions. Four recommendations are made on the basis of a review of the sociological and social epidemiology literature on residential segregation: (1) develop multilevel research designs to examine the effects of individual, neighborhood, and metropol...

Segregation measures are useful tools for the analysis of patterns, causes and effects of residential segregation. However, most of empirical segregation studies have employed nonspatial and global measures. In other words, the measures so far applied are unable to consider the spatial arrangement of population and to show how much each areal unit contributes to the segregation degree of the wh...

Context. The observed presence of pure CO2 ice in protostellar envelopes, revealed by a double peaked 15 μm band, is often attributed to thermally induced ice segregation. The temperature required for segregation is however unknown because of lack of quantitative experimental data and this has prevented the use of ice segregation as a temperature probe. In addition, quantitative segregation stu...

We present a new method to detect and quantify mass segregation in star clusters. It compares the minimum spanning tree (MST) of massive stars with that of random stars. If mass segregation is present, the MST length of the most massive stars will be shorter than that of random stars. This difference can be quantified (with an associated significance) to measure the degree of mass segregation. ...

Race and class factors have been studied as underlying causes of segregation for many years. Individual choices on race and economic constraints of living in one area versus another play an important role in residential segregation. An attempt has not yet been made to simulate the interplay of neighbourhood racial and economic composition in forming segregation using empirical micro-level data....

This paper examines the relationship between racial segregation and poverty. Using data primarily from the 2000 Census, I control extensively for metropolitan area characteristics and other factors. In addition, I use metropolitan area physical geography characteristics as instruments for racial segregation as one approach to address the problem of endogeneity bias. I find significant and posit...

The aim of this paper is to analyze occupational segregation in the Spanish labor market from a gender and an immigration perspective. In doing so, several local and overall segregation measures are used. Our results suggest that immigrant women in Spain suffer a double segregation since segregation affects them to a greater extent than it does either native women or immigrant men. There are, h...