Segmental aneuploidy can play an important role in environmental adaptation. However, study of segmental aneuploids is severely hampered by the difficulty of creating them in a designed fashion. Here, we describe a PCR-mediated chromosome duplication (PCDup) technology that enables the generation of segmental aneuploidy at any desired chromosomal region in Saccharomyces cerevisiae. We construct...

Segmental duplications, or low-copy repeats, are common in mammalian genomes. In the human genome, most segmental duplications are mosaics consisting of pieces of multiple other segmental duplications. This complex genomic organization complicates analysis of the evolutionary history of these sequences. Earlier, we introduced a genomic distance, called duplication distance, that computes the mo...

STUDY DESIGN A systematic review of randomized controlled trials. OBJECTIVES To evaluate the effectiveness of segmental stabilizing exercises for acute, subacute and chronic low back pain with regard to pain, recurrence of pain, disability and return to work. METHODS MEDLINE, EMBASE, CINAHL, Cochrane Controlled Trials Register, PEDro and article reference lists were searched from 1988 onwar...

BACKGROUND Segmental vitiligo is characterized by a unilateral and localized distribution. So far, the underlying mechanism is still an enigma. OBJECTIVES  To get an insight into the aetiopathogenesis of segmental vitiligo by comparison with the distribution pattern of dermatoses with a possible mosaic or neurogenic background. METHODS In this retrospective observational study the distribut...

Previous experimental evidence suggested that the avian segmental pattern is already specified in the apparently unsegmented paraxial (segmental plate) mesoderm, but is susceptible to modification and reconstitution. We explored capacities of embryos to alter the specified pattern and restore it after disruption. In control experiments, right segmental plates of chicken or Japanese quail embryo...

Arvaniti, Ladd and Mennen (1998) reported a phenomenon of ‘segmental anchoring’: the beginning and end of a linguistically significant pitch movement are anchored to specific locations in segmental structure, which means that the slope and duration of the pitch movement vary according to the segmental material with which it is associated. This finding has since been replicated and extended in s...

Steroid-resistant nephrotic syndrome (SRNS) is a clinically and genetically heterogeneous disorder caused by either genetic or immunological factors their combination. Approximately 30-40% of patients with SRNS make fast progression to end-stage renal disease (ESRD). represents the second leading cause ESRD in individuals under age 25 years worldwide. Patients typically exhibit focal segmental ...

OBJECTIVE To assess the sensitivity of noninvasive virtual bronchoscopy based on multirow detector CT scanning in detecting and grading central and segmental airway stenosis using flexible bronchoscopic findings as the reference standard. MATERIALS AND METHODS In a blinded controlled trial, multirow detector CT virtual bronchoscopy and flexible bronchoscopy were used to search for and grade a...

The segmental branches of the renal artery vary in number and origin. The 1998, Terminologia Anatomica homologates two branches of the renal artery (anterior, posterior) and five segmental arteries: four from the anterior branch and one from the posterior one. The purpose of this study is to evaluate the renal artery branching pattern, the number and origin of the segmental arteries, as well as...