Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production the mitochondrial electron transport chain (ETC) and hypoxia-induced factor (HIF)-1 signaling; however, their contribution to EV unknown. We found marker in our reporter cell line CD9truc-EGFP was unaffected HIF-1α stabilizer roxadustat; yet, ETC stimulation dichloro...

Although thyroid hormones are known to influence acid secretion, but exact mechanisms are not fully understood. So, in this experimental study carbachol, histamine, and pentagastrin were used to stimulate acid secretion in isolated stomach of hypo- and hyperthyroid rats and data were compared with controls. Each group consisted of 8 N-Mari rats from both sexes weighing 246 ± 5 g. Hypo- and hype...

In this study, five carp pituitary glands were collected and dispersed enzymatically and mechanically.Then, the cells were cultivated as monolayer in MEM (minimum essential medium Eagle). The culture mediawere collected after 72 h and frozen at -20°C. Carp ovarian follicles also were separated mechanically andincubated in BSS (basic salt solution) Cortland medium in 24-well microplates for 48 h...

This pre-clinical study investigated the transient receptor potential ankyrin-1 (TRPA1) channels on modulating targets for glucose homeostasis using agonists: electrophilic agonists, cinnamaldehyde (CIN) and allyl isothiocyanate (AITC), non-electrophilic agonist, carvacrol (CRV). A tolerance test was performed rats. CIN AITC (5, 10 20 mg/kg) or CRV (25, 100, 300, 600 were administered intraperi...

in this study, five carp pituitary glands were collected and dispersed enzymatically and mechanically.then, the cells were cultivated as monolayer in mem (minimum essential medium eagle). the culture mediawere collected after 72 h and frozen at -20°c. carp ovarian follicles also were separated mechanically andincubated in bss (basic salt solution) cortland medium in 24-well microplates for 48 h...

objective(s): prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (nahs) but effect of nahs on mrna expression of prostaglandin e2 receptors (ep1, 3-4; eps) has not been investigated. therefore, this study designed to evaluate the effect of nahs on mrna expression of eps receptors in response to mucosal acidification and distention-induced gastric acid ...

Background: Pectic acid extracted from plants increases the secretion of prolactin (PRL) when injected intravenously into ewes or fed to rats. Fragments of ewe hypophysis and lactating rabbit mammary gland incubated in vitro in the presence of pectic acid secreted more PRL and caseins compared to the controls. However, it is not known whether pectic acid directly stimulates PRL secretion in pi...