STUDY QUESTION What is the effect of letrozole on the expression of steroid receptors in the placentae in cases of termination of pregnancies? SUMMARY ANSWER The expression of estrogen receptor-α (ERα) and progesterone receptor (PR) transcripts, as well as ERα protein, in placentae was suppressed by letrozole pretreatment in second trimester termination of pregnancy. WHAT IS KNOWN ALREADY T...

OBJECTIVE Comparing sublingual and vaginal misoprostol in second trimester pregnancy termination. MATERIALS AND METHODS In this study 268 women at 12-24 weeks of gestation candidate for pregnancy termination were enrolled. Women were randomly divided in two groups. The first group received 400 µg sublingual misoprostol and vaginal placebo and the second group received 400 µg vaginal misoprost...

Termination of pregnancy in the second and early third trimesters has always been a common challenge in obstetrical practice. In the United States dilation and evacuation in the second w x trimester is preferred 1 , while in the United w x Kingdom prostaglandin analogues are favored 2 . Between November 1995 and June 1998, 43 consecutive pregnant women underwent termination of pathological preg...

Two hundred and eleven patients who had undergone vaginal termination and were pregnant again were investigated; 43-2% had become pregnant within one year of termination. The overall fetal loss in the 211 patients was 17-5% compared with 7-5% in a group matched for parity but consisting of patients who were pregnant after a spontaneous abortion. Altogether 4-3% of pregnancies after legal aborti...

Objective: The purpose of this study is to show distribution of risk in pregnancies which underwent first trimester combined tests, and investigate general demographic and clinical characteristics of patients, underwent invasive diagnostic tests after screening tests. Methods: Combined test data of first trimester screening in 20082011 were evaluated retrospectively and cross-sectional. After t...

background: placenta accreta is a rare obstetrical condition that mainly occurs in the third trimester leading to life-threatening complications. hereby, a case of uterine rupture due to placenta accreta occuring in the second trimester is presented. case presentation: a forty-year old patient who conceived after in vitro fertilization treatment (oocyte donation and embryo transfer) presented i...

OBJECTIVE To examine whether a previous caesarean section increases the risk for complications in women undergoing a mid-trimester pregnancy termination by labour induction. DESIGN Retrospective analysis of case records between 1997 and 2002. SETTING Fetal Medicine Unit of a large teaching hospital. POPULATION One hundred and eight women with a previous caesarean section (study group) and...

Background: To identify an effective misoprostol-only regime for the termination of second trimester pregnancy. Objectives: To compare the efficacy, safety and acceptability of sublingual and vaginal misoprostol for second trimester pregnancy termination. Methods: In a prospective randomized comparative study, over 138 pregnant women at 13 20 weeks (91 140 days) of gestation requiring medical a...

BACKGROUND As comparisons of modern medical and surgical second trimester termination of pregnancy (TOP) are limited, and the optimum method of termination is still debated, an audit of second trimester TOP was undertaken, with the objective of comparing the outcomes of modern medical and surgical methods. METHODS All cases of medical and surgical TOP between the gestations of 13 and 20 weeks...

In this issue of NEJM Evidence, Dr. Goulding and colleagues present the case a patient with second-trimester rupture membranes managed expectantly despite patient’s request for termination her nonviable pregnancy.1 This occurred in Texas, one states that immediately passed even more restrictive laws when Supreme Court’s decision Dobbs v. Jackson Women’s Health Organization ended person’s consti...