Abnormal uterine perfusion detected by Doppler sonography reflects impaired trophoblast invasion, a factor involved in the pathogenesis of pregnancy complications such as preeclampsia or intrauterine growth retardation. Recent studies have demonstrated an autoantibody against the angiotensin type 1 (AT1) receptor in pregnant women with preeclampsia. Our aim was to determine whether the AT1 auto...

BACKGROUND Second trimester pregnancy induction with misoprostol in women with prior caesarean delivery is not well studied. OBJECTIVE To estimate the risk of uterine rupture using misoprostol as an induction agent for pregnancy termination in the second trimester of pregnancy in women with prior caesarean delivery. SEARCH STRATEGY Cases of women with a history of prior caesarean delivery a...

abortion is an important problem in obstetrics throughout the world. the common and standard method for pregnancy termination at first trimester is surgery (curettage). nowadays, an effective method of pregnancy termination at first trimester is medical treatments. the aim of this study is to compare misoprostol alone or in combination with methotrexate for pregnancy termination at first trimes...

Syphilis in pregnancy remains an important medical condition due to its consequences. We present two cases of young pregnant women who were diagnosed syphilis during their antenatal visit. The first case was a 29-year-old Malay lady diagnosed with syphilis during the first trimester of pregnancy, while the second case was a 21-year-old Chinese lady diagnosed with syphilis during the third trime...

OBJECTIVE To study the pregnancy outcomes in first trimester vaginal bleeding. MATERIALS AND METHODS This cross sectional study was done on 60 pregnant women with first trimester vaginal bleeding referring to university hospitals affiliated to Islamic Azad University, Tehran, Iran. All women were evaluated for the outcomes including abortion, preterm rapture of membranes, preterm labor, secon...

It is still unclear to which extent methyl-group intake during pregnancy can affect maternal global DNA (hydroxyl)methylation. Pregnancy methylation profiling and its link with methyl-group intake in a healthy population could enhance our understanding of the development of pregnancy related disorders. One hundred forty-eight women were enrolled in the MANOE (MAternal Nutrition and Offspring's ...

OBJECTIVE Reduced lopinavir concentrations have been demonstrated with use of the capsule formulation during the third trimester of pregnancy. This study determined lopinavir exposure with an increased dose of the new tablet formulation during the third trimester. DESIGN International Maternal Pediatric Adolescent AIDS Clinical Trials 1026s is a prospective nonblinded pharmacokinetic study in...

Pregnancy associated breast cancer is cancer occurring during pregnancy and up to one year post delivery. Local oncologists have strong reservations about administering adjuvant chemotherapy for gestational breast cancer. I present a 31 year old University graduate with early left breast cancer in first trimester that had adjuvant chemotherapy administered from the second trimester. She had a n...