The performance of cardiopulmonary bypass (CPB) in the factor XII-deficient patient is challenging in that the normal method for monitoring anticoagulation is ineffective as a result of an impaired contact activation system. We report the case of a factor XII-deficient patient who underwent surgical revascularization on CPB. His factor XII level was replenished with fresh-frozen plasma immediat...

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Pompe disease is a lysosomal storage disorder associated with systemic deficiency of acid α-glucosidase (GAA). Respiratory-related problems in Pompe disease include hypoventilation and upper airway dysfunction. Although these problems have generally been attributed to muscular pathology, recent work has highlighted the potential role of central nervous system (CNS) neuropathology in Pompe motor...

A healthy Japanese male had reduced factor XII (FXII) activity (35%) in contrast to normal antigen levels (81%). The F12 of this proband had a 9775G to C mutation in exon 10 and an 11276G to A mutation in exon 13 that resulted in two amino acid substitutions of Ala324Pro (GCG→CCG) in the proline-rich connecting region and Gly531Glu (GGG→GAG) near the active Ser544 in the catalytic domain. His f...

Anomaly detection is a crucial task for hyperspectral image processing. Most popular methods detect anomalies at the pixel level, while few algorithms anomaly only utilize subpixel level unmixing technology to extract features without fundamentally analyzing anomalies. To better and separate from background, this paper proposes dual-view method by taking account of analysis both levels mentione...

We have generated a monoclonal antibody against a synthetic peptide whose sequence was derived from the nucleotide sequence of a cDNA encoding alpha 1(XII) collagen. The antibody, 75d7, has been used to identify the alpha 1(XII) chain on immunoblots of SDS-PAGE tendon extracts as a 220-kD polypeptide, under reducing conditions. Amino-terminal amino acid sequence analysis of an immunopurified cy...

Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the intrinsic coagulation pathway factor XI. Prostate cancer cells and secreted prost...

Norepinephrine has powerful and diverse modulatory effects on hypoglossal (XII) motoneuron activity, which is important in maintaining airway patency. The objective was to test two hypotheses that alpha2-adrenoceptor-mediated, presynaptic inhibition of glutamatergic inspiratory drive (Selvaratnam SR, Parkis MA, and Funk GD. Brain Res 805: 104-115, 1998) and postsynaptic inhibition of the hyperp...

The water inrush from the roof of coal mine is closely related to movement failure overburdened rock and height water-conducting fracture zone. In this work, based on research background disaster prevention control No. 2 seam roofs in Jinxinda Coal Mine, stability characteristics overlying working face are analyzed through combining theoretical analysis numerical simulation. According theory ke...

Graphs appear in a wide range of settings, such as computer networks, the world wide web, biological networks, social networks (MSN/FaceBook/LinkedIn) and many more. How can we find user-specific patterns (e.g., master mind, money laundry ring) from such graphs? How can we spot anomaly in a dynamic and intuitive way? How can we find the communities with optional constraints? How can we mine tim...