CHEST, 74: 6, DECEMBER, 1978 to an evaluation of whether those who sought medical help fared any differently from those who did not. In our view, scientific evaluation of the usefulness of detecting high-risk individuals is the next step, an evaluation which is no less a “therapeutic trial” than the large-scale trials of drugs today that are conducted with the precision which comes from good ex...

Hearing loss is a confounding variable that is rarely addressed in behavioral research despite its prevalence across the life span. Currently, the most common method of experimental control over hearing acuity is through self report of perceived impairment. We argue that this technique may lack sensitivity and that researchers should more commonly utilize standardized hearing screening procedur...

In 2007, the Human Fertilisation and Embryology Authority in London, UK, published "Hybrids and Chimeras: A Report on the Findings of the Consultation", which summarized a public debate about research on, and suggested policy for, human animal chimeras [4]. The HFEA formulated the report after conducting a series of surveys and debates from earlier in 2007. The HFEA issued a statement in Septem...

Little is known about how adolescents experience clinical trials. We assessed the experiences of South African adolescent participants in a clinical trial, employing semi-structured interviews to gather qualitative data on the experiences and effects of trial participation. Despite misunderstanding certain concepts regarding assent and trial processes subsequent to enrollment, participants repo...

OBJECTIVE To review psychosocial issues family physicians might wish to be aware of when discussing genetic testing for predisposition for cancer with their patients. QUALITY OF EVIDENCE Articles from academic journals were reviewed. Studies provided level II and III evidence. MAIN MESSAGE Family physicians should be prepared to explore their patients' decisions for or against genetic testi...

In 2007, the Human Fertilisation and Embryology Authority in London, UK, published "Hybrids and Chimeras: A Report on the Findings of the Consultation", which summarized a public debate about research on, and suggested policy for, human animal chimeras [4]. The HFEA formulated the report after conducting a series of surveys and debates from earlier in 2007. The HFEA issued a statement in Septem...