Taxol (paclitaxel), a promising agent for use in ovarian and breast cancer, was incorporated into lipid vesicles (liposomes) composed of different saturated and unsaturated phosphatidylcholines, as well as saturated phosphatidylcholines mixed with the anionic phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylserine (DMPS) at different molar ratios, to yield information about Taxol-liposome ...

Accumulation of lipids in nonadipose tissues can lead to cell dysfunction and cell death, a phenomenon known as lipotoxicity. However, the signaling pathways and mechanisms linking lipid accumulation to cell death are poorly understood. The present study examined the hypothesis that saturated fatty acids disrupt endoplasmic reticulum (ER) homeostasis and promote apoptosis in liver cells via acc...

in this study, both the presence and concentration of some unsaturated compounds in hexane extracts of different parts of anthemis talyschensis showing absorption at wavelength 280-450 nm were surveyed, with the view of possibly using extracts of this plant in new formulations of sunscreen creams. the hexane extracts of flower, leaf and stem of a. talyschensis , collected from northwest iran, w...

Whereas most of the cellular phosphatidylinositol (PI) contain unsaturated fatty chains and are excluded from rafts, GPI-anchored proteins (APs) unusually contain two saturated fatty chains in their PI moiety, and they are typically found within lipid rafts. However, the origin of the saturated chains and whether they are essential for raft association are unclear. Here, we report that GPI-APs,...

We use a liquid-crystal model to predict that hybrid lipids (lipids that have one saturated and one unsaturated tail) can stabilize line interfaces between domains in mixed membranes of saturated lipids, hybrid lipids, and cholesterol (SHC membranes). The model predicts the phase separation of SHC membranes with both parabolic and loop binodals depending on the cholesterol concentration, modele...

changes in the fatty acid content, during frozen storage at -24°c of caspian kutum (rutilus frisii kutum), golden grey mullet (liza aurata), common carp (caprinus carpio), pike perch (sander lucioperca) and common kilka (clupeonella cultiventris caspia), caught from south caspian sea were studied in the present work. changes in saturated fatty acids (sfas), monounsaturated fatty acids (mufas), ...

abstract the coupled modflow-hydrus software package was used to produce a saturated-unsaturated flow model for a flood spreading system (fss) and its associated aquifer. the study aim to improve simulations of near-surface hydrological processes, including temporal and spatial variation in groundwater recharge rates. the coupled model was built with average rmse=1.1 and 1.3 for calibration and...

The Flow through saturated-unsaturated porous media is extremely important in various natural and industrial based applications. While the Darcy's law with various modifications are used to model the flow through a porous media, the flow through unsaturated porous media is largely based on conservation of mass and modified Darcy's law where non-linear relationship exists between the p...

The uptake of free fatty acids has previously been shown to affect the capping of lymphocytes, and there is evidence that different types of fatty acids may partition into separate lipid domains in cell surface membranes. In studies of gel-filtered human platelets, we found that cis-unsaturated fatty acids (1-35 microM) inhibited platelet shape change, aggregation, and secretion of 5-hydroxytry...