Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology. There is evidence that Tumor Necrosis Factor alpha (TNF-α) antagonists are useful in the treatment of advanced or refractory disease. However, sarcoidosis-like reaction has been reported with TNF-α blockade in other inflammatory conditions. Here we report a case of sarcoid-like reaction in a patient with psoria...

Lymph node swelling in the setting of malignancy generally suggests metastasis of the primary tumor. A granulomatous reaction, i.e. sarcoid reaction, occurring within the lymph nodes draining carcinomas is a well-known but uncommon occurrence. The phenomenon is especially rarely seen in colon carcinoma. We herein report a rare case of a 56-year-old Japanese male with adenocarcinoma of the ascen...

Sarcoidosis is a systemic granulomatous disorder of unknown etiology, characterized by chronic noncaseating epitheloid granulomatous inflammation with tissue destruction [1,2]. Renal involvement affects 20% of patients with sarcoidosis [1,2] and can be found in patients with no other localizations of the disease [3]. A common cause of renal dysfunction is hypercalcaemia and hypercalciuria leadi...

Sarcoid reactions are relatively rare manifestations of epithelioid cell granulomas associated with malignancy; they are especially found in the lymph nodes draining malignant tumors, but rarely found in other organs. We present a case of a 60-year-old female with sarcoid reactions in the spleen identified during the consecutive diagnosis and management of ovarian, breast, and thyroid carcinoma...

Central nervous system (CNS) lesions, mainly involving the meninges, are found in up to 16% of autopsy studies of patients with known sarcoidosis [1]. Primary CNS sarcoid granuloma without systemic disease is seen in only about 5% of patients [2]. The characteristic MRI appearance of chiasmal sarcoidosis is peripheral contrast enhancement resulting from meningeal involvement. We report a rare c...

A diagnosis of sarcoidosis was evoked in a 61-year-old man on clinical and histologic bases. Nevertheless, a bile duct carcinoma was disclosed in association with the discovery of generalized sarcoid-like granulomas. This is only the third time that such an association has been described. HLA-B8, DR3, and DRw52 antigens were found, suggesting that altered immunologic mechanisms could play a rol...

S ARCOIDOSIS is considered to be a granulomatous process that affects multiple systems. Neurologic symptoms develop in 1% to 2% of cases with Boeck’s sarcoid.’ Although the neurologic presentation has been uncommon, granulomas have been observed in up to 14% of patients with sarcoid at autopsy.’ The purpose of this presentation is to demonstrate the protean manifestations of sarcoidosis within ...

OBJECTIVE To describe a patient with an acute fulminant delirium and eventual spinal fluid block secondary to sarcoid meningitis. DESIGN Case report. SETTING Hospital and Neurology Clinic. PATIENT A previously healthy, 24-year-old man. INTERVENTIONS Antimicrobials, corticosteroids, lumbar puncture, myelography, and lymph node biopsy. MAIN OUTCOME MEASURES Cerebrospinal fluid, clinical...

BACKGROUND Bovine papillomaviruses (BPVs) types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to neoplastic skin lesions in equids termed sarcoids. The equine sarcoid is considered to be the most common equine cutaneous tumour worldwide for which no effective therapy is avail...

Sarcoid reactions are relatively rare manifestations of epithelioid cell granulomas associated with malignancy; they are especially found in the lymph nodes draining malignant tumors, but rarely found in other organs. We present a case of a 60-year-old female with sarcoid reactions in the spleen identified during the consecutive diagnosis and management of ovarian, breast, and thyroid carcinoma...