The aromathecin topoisomerase I (top1) inhibitors offer promising scaffolds for the development of novel cancer chemotherapeutics. They are 'composites' of the camptothecin and indenoisoquinoline top1 inhibitors. Interestingly, some structure-activity relationship (SAR) overlap between the aromathecins and the indenoisoquinolines has been observed. For both classes, placement of certain polar g...

Due to uncertainty on target's motion, the range cell migration (RCM) and azimuth phase error (APE) of moving targets can't be completely compensated in synthetic aperture radar (SAR) processing. Therefore, moving targets often appear two-dimensional (2-D) defocused in SAR images. In this paper, a 2-D autofocus method for refocusing defocused moving targets in SAR images is presented. The new m...

In mono-polarized synthetic aperture radar (SAR) imagery, GI distribution often is assumed as the universal model to characterize a large number of targets, which is indexed by three parameters: the number of looks, the scale parameter, and the roughness parameter. The latter is closely related to the number of elementary backscatters in each pixel, and it is the reason why so many researchers ...

Synthetic aperture radar (SAR) tomography is a powerful approach to investigate the relationship between 3-D radar backscattering and physical structure of agricultural vegetation, which is not fully understood yet. In this paper, the focus is set on the characterization of polarimetric scattering and propagation effects within the vegetation layer as a function of species, time and frequency. ...

Allergic rhinitis (AR) is a very frequent disease which is not only characterized by nasal symptoms, but also with behavioural changes. This study evaluated the serum serotonin levels in patients with pollen-induced AR during and outside the pollen season.One-hundred-two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with seasonal AR (SAR) evaluated outside the p...

Pulmonary sensory receptors are the initiating sites for lung reflexes; however, little is known about their structure, especially the relationship between the structure and function of these receptors. Using a novel approach (combining electrophysiological and morphological techniques), we examined the structures of the typical slowly adapting pulmonary stretch receptors (SARs) located in the ...

We present an explanation for the widely reported power-law species-area relationship (SAR), which relates the area occupied by a biome to the number of species that it supports. We argue that power-law SARs are a robust consequence of a skewed species abundance distribution resembling a lognormal with higher rarity, together with the observation that individuals of a given species tend to clus...

A framework is formulated for the development of a predictive structure-activity relationship for the temperature-dependent rate coefficients of H-migration in substituted alkoxy radicals. It is based on a multi-conformer transition state theory model, using quantum chemical characterizations of alkoxy radicals and their transition states for isomerisation. Using this framework, a SAR is then d...

N-[1-(2-Phenylethyl)-piperidin-4-yl]-propionamide (fentanyl) is the prototype of the 4anilidopiperidine class of synthetic opioid analgesics. This study was aimed to review the best method of synthesis and to determine the Structure-Activity-Relationship (SAR) of fentanyl analogs. The best method of synthesis of fentanyl is the method described in International Application No.: PCT/IN2009/00015...