Metabolic syndrome and related disorders are increasingly prevalent in contemporary society, and thus pose the need for potent agents to control lipid accumulation in the body. This study indicates that Caenorhabditis elegans was effective in screening for potent lipid metabolism modulators with berberine as a model compound. Among the various isoquinoline alkaloids tested, sanguinarine, a benz...

This research included two studies evaluating the live performance of broilers fed Sangrovit (minimum of 1.5% sanguinarine, a quaternary benzo[c]phenanthridine alkaloid extracted from Macleaya cordata). Both studies were conducted using Ross 308 female broiler chicks. Birds were fed corn-soybean meal all-vegetable diets without growth promoters with 5 treatments and 8 replications in each study...

UNLABELLED The aim of this study was to investigate the apoptosis resulting from NSC 95397, brefeldin A, bortezomib and sanguinarine in neuroendocrine tumor cell lines. MATERIALS AND METHODS A multiparametric high-content screening assay for measurement of apoptosis was used. The human pancreatic carcinoid cell line, BON-1, human typical bronchial carcinoid cell line NCI-H727 and the human at...

Sanguinaria canadesis, Chelidonium majus and Macleya cordata have been used for centuries as alternative medicines. Currently the extracts from these medicinal plants are components of veterinary and human phytopreparations, and of oral-hygiene agents. Sanguinarine and chelerythrine (SA/CHE) are biologically active components of these extracts. They display distinct antibacterial and anti-infla...

in vivo and in vitro sublethal exposure of abrin, glycyrrhizin (active component of abrus precatorius seed and root), sanguinarine, protopine (argemone mexicana seed) and oleandrin (nerium indicum leaf) inhibited the acetylcholinesterase, lactic dehydrogenase, acid and alkaline phosphatase activity in the nervous tissue of lymnaea acuminata. the succinic dehydrogenase activity in the nervous ti...

A strong molluscicidal effect of sanguinarine against Oncomelania hupensis snails was demonstrated by immersion test in the present study. A positive relationship between doses, immersion time and the mortality of the snails was exhibited, while the optimal dose and immersion time of application towards the field eradication of snails were suggested. The possible mechanisms of effects were expl...