Group A streptococcus (GAS) is an important human pathogen that causes pharyngitis and invasive infections, including necrotizing fasciitis. Streptolysin S (SLS) is the cytolytic factor that creates the zone of beta-hemolysis surrounding GAS colonies grown on blood agar. We recently reported the discovery of a potential genetic determinant involved in SLS production, sagA, encoding a small pept...

Present address: =Cell Cycle Control Group, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK. ^Nomura Research & Advisory Co. Ltd., Urbannet Otemachi Building 2-2-2, Otemachi, Chiyoda-ku, Tokyo100-8130, JAPAN. +Center for Gene Science, Hiroshima University, 1-4-2 Kagamiyama, Higashi-Hiroshima 739-8537, Japan. ~Analytical Research Centre for Experimental Sciences, Saga Univer...

Hiroyuki Fujiwara ([email protected]) Akihiro Shimoda ([email protected]) Yoshiki Ishikawa ([email protected]) Akiyo Taneichi ([email protected]) Mai Ohashi ([email protected]) Yoshifumi Takahashi ([email protected]) Takahiro Koyanagi ([email protected]) Hiroyuki Morisawa ([email protected]) Suzuyo Takahashi ([email protected]) Naoto Sato (nao-...

Removal of S-Methylmethionine Sulfonium from Satsuma Mandarin Juice Yutaka OSAJIMA, Mitsuya SHIMODA, Hisao MAEDA* and Shozo UENO** Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka 812 * Wakayama Agricultural Processing Research Corporation , Momoyama-cho, Naga-gun, Wakayama-ken 649-61 ** Saga-ken Horticultural Growers Co-operative Association , Ogi-c...

'Department of Mechanical Engineering Faculty of Science and Engineering "Department of Advanced Systems Oontrol Engineering, Graduate School of Scienoe and Engineering, "'Faculty of Engineering Systems and Technology, Graduate Schoo: of Science and Engineerin& Saga University 1-Honjomachi, Saga 840-85on, Japan E-mail; {izumi, watanabe}@me.saga-u.ac.jp paeoeived June as, 1998; aocepted Novernbe...

In Saccharomyces cerevisiae, core promoters of class II genes contain a TATA element, either a TATA box (TATA[A/T]A[A/T][A/G]) or TATA-like element (1 or 2 bp mismatched version of the TATA box). The TATA element directs the assembly of the preinitiation complex (PIC) to ensure accurate transcriptional initiation. It has been proposed the PIC is assembled by two distinct pathways in which TBP i...

Succinylated Acinetobacter glutaminase-asparaginase (SAGA) has broader antitumor activity than Escherichia coli L-asparaginase in experimental systems; moreover, drug resistance does not develop in tumor cell lines initially sensitive to this enzyme. We have investigated the pharmacology and toxicology of SAGA after both single-dose and serial daily dose injections in 20 adult patients. Glutami...

Despite the availability of several large-scale proteomics studies aiming to identify protein interactions on a global scale, little is known about how proteins interact and are organized within macromolecular complexes. Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild-type and deletion strains ...

1Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan; 2Astex Therapeutics Ltd, Cambridge, United Kingdom; 3Division of Hematology, Respiratory Medicine, and Oncology, Saga University, Saga, Japan; 4Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; and 5Department of Hematology, Johann Wolfgang Goethe U...