BACKGROUND Sodium antimony gluconate (SAG) unresponsiveness of Leishmania donovani (Ld) had effectively compromised the chemotherapeutic potential of SAG. 60s ribosomal L23a (60sRL23a), identified as one of the over-expressed protein in different resistant strains of L.donovani as observed with differential proteomics studies indicates towards its possible involvement in SAG resistance in L.don...

The mining company uses a variety of grinding machines to process minerals, whereas the most common type machine is Semi-Autogenous Grinding SAG Mill machine. This employed for hard rock as raw material into gold, copper, and silver. However, are often broken, even suddenly not working, with an average loss time 97.30 hours which impacts decrease in efficiency production quality up 40%. It can ...

Sensitive to Apoptosis Gene (SAG), also known as RBX2 (RING box protein-2), is the RING component of SCF (SKP1, Cullin, and F-box protein) E3 ubiquitin ligase. Our previous studies have demonstrated that SAG is an anti-apoptotic protein and an attractive anti-cancer target. We also found recently that Sag knockout sensitized mouse embryonic stem cells (mES) to radiation and blocked mES cells to...

An expert system applied to the control of mineral process unit operations is, by its nature, the site best operating practice, having been designed by the local experts in conjunction with consulting metallurgists. The “common sense” layer in a MET (MinnovEX Expert Technology) solution determines an appropriate action for the current operating conditions through a developed heuristic model of ...

BACKGROUND & OBJECTIVES Sodium antimony gluconate (SAG) is reported to be losing its efficacy in Bihar as a first line drug for treatment of visceral leishmaniasis (VL). Concerned with the increasing incidence of antimony-resistant VL patients in Bihar, we undertook an epidemiological, clinical and pharmacological study to formulate a scientific basis for choosing a suitable first line drug for...

PURPOSE Oguchi's disease is a rare autosomal recessive disease and known to be caused by mutations in the rhodopsin kinase (GRK1) gene or the arrestin (SAG) gene. SAG contains 16 exons and encodes a protein with 405 amino acids. This study was to identify the underlying genetic defects in a non-consanguineous Chinese family with Oguchi's disease. METHODS Ophthalmologic examinations including ...

BACKGROUND AND OBJECTIVES Cardiovascular outcomes and mortality rates are poor in advanced chronic kidney disease (CKD) patients. Novel risk factors related to clinical outcomes should be identified. METHODS A retrospective analysis of data from a randomized controlled study was performed in 440 CKD patients aged > 18 years, with estimated glomerular filtration rate 15-60 mL/min/1.73m2. Clini...

Although neurons are known to exhibit a broad array of intrinsic properties that impact critically on the computations they perform, very few studies have quantified such biophysical diversity and its functional consequences. Using in vivo and in vitro whole-cell recordings here we show that mitral cells are extremely heterogeneous in their expression of a rebound depolarization (sag) at hyperp...

Voltage sag/swell is one of the most frequently power quality problems which affects the power systems with sensitive loads. The unified power quality conditioner (UPQC) is capable of mitigating the effect of voltage sag/swell at the load or point of common coupling (PCC). In this paper, a new control of UPQC is proposed based on combining the sag detection and voltage injection established on ...

By quick technological advancements in industrial control processes, major industries demand higher power quality. According to IEEE 1159-1995 standard, any problems in voltage, current or freq‌ue‌ncy that lead to the error or malfunctions in electrical equipment are considered as a power quality problem. Among the power quality phenomena, voltage sag has been an important problem for power sys...