BACKGROUND Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed proteins in resistant isolates, as observed in differential proteomics betwe...

BACKGROUND In radiotherapy treatments, it is crucial to monitor the performance of linac components including gantry, collimation system, and electronic portal imaging device (EPID) during arc deliveries. In this study, a simple EPID-based measurement method is suggested in conjunction with an algorithm to investigate the stability of these systems at various gantry angles with the aim of evalu...

Superantigens (SAg) are a family of bacterial and viral proteins with strong immunostimulatory properties. SAg bound to major histocompatibility complex (MHC) class II molecules activate a high frequency of T cells and represent the most potent known activators of T cells to date. To explore the use of SAg for T cell-based tumor therapy we have created a tumor-reactive SAg by engineering a fusi...

Elucidating the role of carbohydrate quality in human nutrition requires a greater understanding of how the physico-chemical characteristics of foods relate to their physiological properties. It was hypothesised that rapidly available glucose (RAG) and slowly available glucose (SAG), in vitro measures describing the rate of glucose release from foods, are the main determinants of glycaemic inde...

7 International Conference on Head-driven Phrase Structure Grammar, Berkeley 22 July 2000 Aims: 1⁄2 Supporting the ARG-ST / DEPS / VALENCE distinction 1⁄2 Working towards a theory of diathesis and diathetic paradigmatic relations in HPSG 1⁄2 Reconsidering phenomena that are sensitive to subject prominence 1⁄2 Possibilities of making compatible the insightful HPSG analyses of binding (Manning an...

The aim of this research work was to investigate on the ball filling estimation of Miduk semi-autogenous (SAG) Mill via an utilized method. Miduk copper concentrator is located in Kerman Province, Iran, and its size reduction stage includes one gyratory crusher which feeds one SAG mill (9.75 dia.(m)*3.88 length(m)) following two parallel ball mills (5dia.(m)*7lenght(m)). After SAG mill, a tromm...

After mouse mammary tumor virus (MMTV) infection, B lymphocytes present a superantigen (Sag) and receive help from the unlimited number of CD4(+) T cells expressing Sag-specific T-cell receptor Vbeta elements. The infected B cells divide and differentiate, similarly to what occurs in classical B-cell responses. The amplification of Sag-reactive T cells can be considered a primary immune respons...

semang (sag), a mutation isolated as a suppressor of Drosophila Src42A, has previously been shown to affect some receptor tyrosine kinase mediated embryonic processes. Here we show that sag specifically affects the development of R1, R6 and R7 photoreceptor cells in a cell-autonomous manner. These cells are absent in the mutant at the time when they normally appear in the ommatidial pre-cluster...

Power quality issues have been a source of major concern in recent years due to extensive use of power electronic devices and non-linear loads in electrical power system. In power systems the common disturbances are voltage sags and swells, usually associated with power system faults. Therefore the effective detection of voltage sags and swells event is an important issue for both voltage sag a...