Granular cell tumor is a rare benign non-encapsulated tumor that mostly presents in oral cavity. Breast localization is uncommon and occurs in about one per 1000 cases of breast cancers. It mainly affects premenopausal women showing the possible role of estrogen and progesterone levels in the progression of this tumor. Granular cell tumor is a great emulator of the invasive ductal carcinoma of ...

Distant metastasis is the predominant cause of death in early-stage non-small cell lung cancer (NSCLC). Currently, it is impossible to predict the occurrence of metastasis at early stages and thereby separate patients who could be cured by surgical resection alone from patients who would benefit from additional chemotherapy. In this study, we applied a comparative microarray approach to identif...

OBJECTIVE To determine whether atrial myxomas express antigens suggesting a neural origin. DESIGN A retrospective analysis based on immunohistochemical examination of myxoma tissue. SETTING Atrial myxomas excised by two tertiary referral cardiothoracic surgical units. SUBJECTS 24 excised atrial myxomas. Three were from known cases of familial myxoma syndrome. METHODS Immunohistochemical...

OBJECTIVE Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions. MATERIALS AND METHODS Immunohistochemical analysis ...

Background: Spindle cell/Sclerosing rhabdomyosarcoma is the rarest variant of rhabdomyosarcoma, accounting for 5-10% all cases. Pathologically, these tumors can provide a variety features and resemble other tumors, thus often difficult to diagnose. We report case sclerosing gingiva with histomorphology mimicking malignant peripheral nerve sheath tumor. Case Presentation: The patient was 39-year...

Hyaluronan-cisplatin conjugate nanoparticles (HCNPs) were chosen as colon-targeting drug-delivery carriers due to the observation that a variety of malignant tumors overexpress hyaluronan receptors. HCNPs were prepared by mixing cisplatin with a hyaluronan solution, followed by dialysis to remove trace elements. The cells treated with HCNPs showed significantly lower viability than those treate...

CONTEXT Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis. OBJECTIVE To review histologic and immunohistochemical aspects of cutaneous spindle cell tumors and discuss a basic panel of markers to assist in the differential diagnosis. DATA SO...

Immunohistology studies play an essential role in the diagnosis and in this type of tumors they are positive for S100 (family of low-molecular weight proteins present in the cells derived from the neural crest) and vimentin (protein found in the cytoskeleton of mesenchymal cells). As for the treatment of suprarenal tumors, surgery is indicated in functioning tumors, in masses with radiological ...