Excessive daytime sleepiness is common in Parkinson's disease and has been associated with Parkinson's disease-related dementia. Narcoleptic features have been observed in Parkinson's disease patients with excessive daytime sleepiness and hypocretin cell loss has been found in the hypothalamus of Parkinson's disease patients, in association with advanced disease. However, studies on cerebrospin...

BACKGROUND/AIMS Sleep disturbances and emotional dysfunction are commonly associated with gastroeophageal reflux disease (GERD). The aims of this study were to evaluate GERD symptoms and disturbance in erosive reflux disease (ERD) and nonerosive reflux disease (NERD) patients, and to compare sleep dysfunction, depressive mood, anxiety and quality of life (QOL) among the control, ERD and NERD pa...

eczema  is  a  common  childhood  atopic  condition and treatment is with emollients,  topical corticosteroids and  avoidance  of  possible  triggers. s.  aurues colonization is a common complication. during exacerbation,  intensification  of treatment  is needed  to relieve   the  child   from   the   miserable   symptoms   of pruritus   and  sleep  disturbance.   systemic   antibiotics agains...

BACKGROUND The aim of this study was to evaluate sleep quality and the related variables in patients with rheumatoid arthritis (RA). METHODS Ninety-four patients diagnosed with RA and fifty two healthy controls were enrolled in the study. Disease activity was assessed through the Disease Activity Score (DAS) 28 scale. All patients were assessed using the Rheumatoid Arthritis Quality of Life a...

OBJECTIVES Irregular working hours severely disturb sleep and wakefulness. This paper presents a modification of the quantitative (computerised) three process model of regulation of alertness to predict duration of sleep in connection with irregular sleep patterns. METHODS The model uses a circadian "C" (sinusoidal) and homeostatic "S" (exponential) component (the duration of previous periods...

AIM The aim of the study was to assess the prevalence of sleep disorders in the preclinical period of the Alzheimer's disease (AD). METHOD The initial population consisted of care centers residents, who had had the presence of dementia excluded. The enrolled patients (n = 2910) underwent the assessment of cognitive functions by means of the ADAS-cog scale, as well as of the severity of sleep ...

Transdermal rotigotine was used in six patients with advanced Parkinson's disease and sleep disorders (UPDRS part II item 12 score ≥ 2) receiving oral levodopa and diurnal apomorphine infusions. Transdermal rotigotine (2-4 mg/24h) was used at night for four months. Sleep disorders improved, the total Parkinson's Disease Sleep Scale score falling by an average of 45%; significant improvements em...

PURPOSE To investigate the association of dry eye disease with sleep quality. METHODS In 2011, a cross-sectional survey was conducted among all the employees, mainly young and middle-aged Japanese office workers, who used visual display technology, at a company in Osaka, Japan (N=672; age range =26-64 years). The participants were classified according to the Japanese dry eye diagnosis criteri...

pompe disease, also termed glycogen storage disease type ii or acid maltase deficiency, caused by deficient activity of acid alpha-glucosidase (gaa), the glycogen degrading lysosomal enzyme. as a result, massive lysosomal glycogen deposits in the numerous organs including the muscles. in pompe disease weakness of truncal muscles is a prominent presentation which results in respiratory failure a...

conclusions the most important factor in diagnosis is physician’s attention and clinical experience with this condition and using irlssg. results two major theories are developed regarding the pathophysiology of rls. the first one concerns central nervous system dopamine imbalance and the second one concerns intracellular iron dysregulation. the most common used pharmacologic agents in treatmen...