IMPORTANCE A number of officially approved disease-modifying drugs (DMD) are currently available for the early intervention in patients with relapsing-remitting multiple sclerosis (RRMS). The aim of the present study was to systematically evaluate the effect of DMDs on disability progression in RRMS. METHODS We performed a systematic review on MEDLINE and SCOPUS databases to include all avail...

BACKGROUND Patients with multiple sclerosis (MS) who are adherent to their treatment regimens are less likely to experience relapses and the cost associated with relapse. Pharmacists whose practice involves these specialty pharmaceuticals used to treat MS are striving for ways to improve outcomes by achieving treatment adherence in their patients. Specialty pharmacies have reported higher adher...

The treatment of multiple sclerosis (MS) is entering a new era, characterized by the availability of a broad range of disease modifying drugs (DMDs) for patients in the relapsing-remitting (RR) phase of the disease. Through interference with immunemediated inflammatory processes the DMDs reduce the number and severity of relapses and the increase in relapse-related disability. Each DMD is chara...

Traditional engineering decision support systems (EDSS) cannot be well applied in the practice of construction management due to their inherent limitations in knowledge acquisition. In this paper, a new approach named DMDS is proposed, which integrates data mining technologies with decision support systems. DMDS aims to automatically extract knowledge from a large amount of historic data genera...

Concentrated livestock feeding operations have become a source of odorous gas emissions that impact air quality. Comprehensive and practical technologies are needed for a sustainable mitigation of the emissions. In this study, we advance the concept of using a catalyst for barn walls and ceilings for odor mitigation. Two catalysts, a new TiO2-based catalyst, PureTi Clean, and a conventional Evo...

[1] Oceanic gross DMS production (GP) exerts a fundamental control on the concentration and the sea‐air flux of this climatically‐active trace gas. However, it is a poorly constrained process, owing to the complexity of the microbial food web processes involved and their interplay with physical forcing, particularly with solar radiation. The “inhibitor method”, using dimethyldisulfide (DMDS) or...

For most imprinted genes, a difference in expression between the maternal and paternal alleles is associated with a corresponding difference in DNA methylation that is localized to a differentially methylated domain (DMD). Removal of a gene's DMD leads to a loss of imprinting. These observations suggest that DMDs have a determinative role in genomic imprinting. To examine this possibility, we i...

The purpose of this study was to assess the adherence to therapy in patients with relapsing remitting multiple sclerosis (RR-MS) and to analyze the possible influence of factors such as hospital care and patients socioeconomic status. Two hundred eighty-five patients with RR-MS according to Mc Donald's criteria and naïve disease-modifying drugs (DMDs) naïve were enrolled. Two self-administered ...