OBJECTIVE to compare healing strength of the infraspinatus tendon of rats with corticoid inoculation, regarding maximum tension, maximum force and rupture force, after injury and experimental repair. METHODS a total of 60 Wistar rats were subjected to tenotomy of the infraspinatus tendon, which was then sutured. Before the surgery, they were divided into a control group (C) inoculated with se...

We show that the static force spectroscopy curve taken in an atomic force microscope is significantly modified due to presence of intrinsic cantilever instability which occurs as a result of its movement in a nonlinear force field. This instability acts in tandem with such instabilities as water bridge or molecular bond rupture and makes the static force spectroscopy curve (including 'jump-off-...

Force generation and motion in skeletal muscle result from interaction between actin and myosin myofilaments through the cyclical formation and rupture of the actomyosin bonds, the cross-bridges, in the overlap region of the sarcomeres. Actomyosin bond properties were investigated here in single intact muscle fibers by using dynamic force spectroscopy. The force needed to forcibly detach the cr...

Leukocytes roll along the endothelium of postcapillary venules in response to inflammatory signals. Rolling under the hydrodynamic drag forces of blood flow is mediated by the interaction between selectins and their ligands across the leukocyte and endothelial cell surfaces. Here we present force-spectroscopy experiments on single complexes of P-selectin and P-selectin glycoprotein ligand-1 by ...

The rupture forces of individual host-guest complexes between beta-cyclodextrin (beta-CD) heptathioether monolayers on Au(111) and several surface-confined guests were measured in aqueous medium by single molecule force spectroscopy using an atomic force microscope. Anilyl, toluidyl, tert-butylphenyl, and adamantylthiols (0.2-1%) were immobilized in mixed monolayers with 2-mercaptoethanol on go...

A random fuse network, or equivalently a 2d spring network with quenched disorder, is submitted to a constant load and thermal noise, and studied by numerical simulations. Rupture is thermally activated and the lifetime follows an Arrhenius law where the energy barrier is reduced by disorder. Due to the non-homogenous distribution of forces from stress concentration at microcracks’ tips, spatia...

rupture and wrinkling are two prevalent phenomena that happen in hydro-forming process. many efforts have been made to achieve the upper and lower bounds for the pressure related to rupture and wrinkling of sheet, respectively. the aim of this investigation is to improve the upper bound of fluid pressure in hydro-forming process by hemispherical punch. in this article, analytical study of the u...

The interaction between single synthesized antigen and its monoclonal antibody was directly monitored by Atomic Force Microscopy (AFM) with antigen-labeled AFM tip. The details about tip modification and antibody immobilization were described. The interactions were monitored by the change of adhesive force in separating the bound antigen-antibody. The results showed that two processes could be ...

Ventilator-induced lung injury is a side-effect of mechanical ventilation. Its prevention or attenuation implies knowledge of the sequence of events that lead from mechanical stress to lung inflammation and stress at rupture. A literature review was undertaken which focused on the link between the mechanical forces in the diseased lung and the resulting inflammation/rupture. The distending forc...