نتایج جستجو برای: runx2

تعداد نتایج: 2482  

2015
Effat Farrokhi Keihan Ghatreh Samani Morteza Hashemzadeh Mohammad Amin Tabatabaiefar

BACKGROUND Vascular calcification is an important stage in atherosclerosis. During this stage, vascular smooth muscle cells (VSMC) synthesize many osteogenic factors such as osteonectin (encoded by SPARC). Oxidative stress plays a critical role in atherosclerosis progression, and its accumulation in the vascular wall stimulates the development of atherosclerosis and vascular calcification. The ...

Journal: :Cancer research 2015
Hanna Taipaleenmäki Gillian Browne Jacqueline Akech Jozef Zustin Andre J van Wijnen Janet L Stein Eric Hesse Gary S Stein Jane B Lian

Progression of breast cancer to metastatic bone disease is linked to deregulated expression of the transcription factor Runx2. Therefore, our goal was to evaluate the potential for clinical use of Runx2-targeting miRNAs to reduce tumor growth and bone metastatic burden. Expression analysis of a panel of miRNAs regulating Runx2 revealed a reciprocal relationship between the abundance of Runx2 pr...

Journal: :Journal of clinical pathology 2005
V B Andela F Siddiqui A Groman R N Rosier

BACKGROUND Dominant negative inhibition of nuclear factor kappa B (NF kappa B) signalling activity in a human osteosarcoma cell line (Saos2) results in malignant reversion and the induction of the osteoblast differentiating transcription factor, Runx2/Cbfa1. This observation suggests that there is an inverse relation between a transcription factor associated with malignant progression and chemo...

2017
Xue-Yan Qin Pei-Zeng Jia Hua-Xiang Zhao Wei-Ran Li Feng Chen Jiu-Xiang Lin

BACKGROUND Cleidocranial dysplasia (CCD) is an autosomal dominant disease that affects the skeletal system. Common symptoms of CCD include hypoplasia or aplasia of the clavicles, delayed or even absent closure of the fontanels, midface hypoplasia, short stature, and delayed eruption of permanent and supernumerary teeth. Previous studies reported a connection between CCD and the haploinsufficien...

Journal: :Developmental dynamics : an official publication of the American Association of Anatomists 2007
Ryan Kerney Joshua B Gross James Hanken

The vertebrate transcription factor protein Runx2 is regarded as a "master regulator" of bone formation due to the dramatic loss of the osseous skeleton in the mouse homozygous knockout. However, Runx2 mRNA also is expressed in the pre-hypertrophic cartilaginous skeleton of the mouse and chicken, where its developmental function is largely unknown. Several tiers of Runx2 regulation exist in the...

Journal: :Archives of histology and cytology 2008
Toshihiro Miyazaki Naoko Kanatani Satoshi Rokutanda Carolina Yoshida Satoru Toyosawa Reiko Nakamura Shinji Takada Toshihisa Komori

Runx2 is an essential transcription factor for bone and tooth development whose function in odontoblast differentiation remains to be clarified. To pursue this issue, we examined tooth development in Runx2 transgenic mice under the control of Col1a1 promoter (Tg(Col1a1-Runx2) mice). Endogenous Runx2 protein was detected in the nuclei of preodontoblasts, immature odontoblasts, mesenchymal cells ...

Journal: :Heliyon 2023

As the most abundant internal mRNA modification, N6-methyladenosine (m6A) RNA methylation has been found to influence many biological events including bone mesenchymal stem cells (BMSCs) osteogenic differentiation. YTH binding protein C2 (YTHDC2) is an m6A reading with ability mediate decay of combined methylated mRNA, however its role in BMSCs differentiation remains unknown. In this study, we...

2010
Jae-Mok Lee Towia A. Libermann Je-Yoel Cho

PURPOSE Bone tissues for clinical application can be improved by studies on osteoblast differentiation. Runx2 is known to be an important transcription factor for osteoblast differentiation. However, bone morphogenetic protein (BMP)-2 treatment to stimulate Runx2 is not sufficient to acquire enough bone formation in osteoblasts. Therefore, it is necessary to find other regulatory factors which ...

Journal: :FEBS letters 2009
Nagarajan Selvamurugan Emi Shimizu Minnkyong Lee Tong Liu Hong Li Nicola C Partridge

Matrix metalloproteinase-13 (MMP-13) plays a critical role in parathyroid hormone (PTH)-induced bone resorption. PTH acts via protein kinase A (PKA) to phosphorylate and stimulate the transactivation of Runx2 for MMP-13 promoter activation. We show here that PTH stimulated Runx2 phosphorylation in rat osteoblastic cells. Runx2 was phosphorylated on serine 28 and threonine 340 after 8-bromo cycl...

Journal: :cell journal 0

objective: runt-related transcription factor 2 (runx2) and osterix (osx) as two specific osteoblast transcription factors and distal-less homeobox 5 (dlx5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (bsp), osteopontin and collagen type iα1. the present study sets out to investigate whether epigenetic regulati...

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