نتایج جستجو برای: running wheel exercise

تعداد نتایج: 261182  

Journal: :Journal of applied physiology 1998
J G Swallow T Garland P A Carter W Z Zhan G C Sieck

An animal model was developed to study effects on components of exercise physiology of both "nature" (10 generations of genetic selection for high voluntary activity on running wheels) and "nurture" (7-8 wk of access or no access to running wheels, beginning at weaning). At the end of the experiment, mice from both wheel-access groups were significantly lighter in body mass than mice from seden...

Journal: :Journal of applied physiology 2000
P Houle-Leroy T Garland J G Swallow H Guderley

Selective breeding is an important tool in behavioral genetics and evolutionary physiology, but it has rarely been applied to the study of exercise physiology. We are using artificial selection for increased wheel-running behavior to study the correlated evolution of locomotor activity and physiological determinants of exercise capacity in house mice. We studied enzyme activities and their resp...

Journal: :Behavioural brain research 2015
Jennifer R Merritt Justin S Rhodes

Moderate levels of aerobic exercise broadly enhance cognition throughout the lifespan. One hypothesized contributing mechanism is increased adult hippocampal neurogenesis. Recently, we measured the effects of voluntary wheel running on adult hippocampal neurogenesis in 12 different mouse strains, and found increased neurogenesis in all strains, ranging from 2- to 5-fold depending on the strain....

Journal: :Journal of applied physiology 2014
James M Kuczmarski Christopher R Martens Jahyun Kim Shannon L Lennon-Edwards David G Edwards

The purpose of this investigation was to determine the effect of 4 wk of voluntary wheel running on cardiac performance in the 5/6 ablation-infarction (AI) rat model of chronic kidney disease (CKD). We hypothesized that voluntary wheel running would be effective in preserving cardiac function in AI. Male Sprague-Dawley rats were divided into three study groups: 1) sham, sedentary nondiseased co...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2006
J P De Bono D Adlam D J Paterson K M Channon

Regular physical exercise has beneficial effects in many human disease states, including cardiovascular diseases, cancer, and depression. Exercise training of genetically modified mouse models may provide insight into the molecular mechanisms that underlie the beneficial effects of exercise. Presently, there is relatively little understanding of the normal physiology of mouse exercise. In this ...

Journal: :Clinical science 2000
N D Duncan D A Williams G S Lynch

The beta(2)-adrenergic agonist, clenbuterol, has powerful muscle anabolic and lipolytic effects and is used by athletes to improve exercise performance; however, its use in conjunction with different forms of exercise training has received limited attention. Since previous studies have reported that chronic use of other beta(2)-adrenergic agonists has deleterious effects on cardiac muscle struc...

2015
Tae-Kyung Kim Jin-Young Park Pyung-Lim Han

BACKGROUND Animal models are necessary to study the mechanism underlying the effects of exercise on depression but an effective procedure for exercise treatment and exercise effects on physiological parameters in a specific depression model need to be characterized. METHODS Physiological parameters including lactate, partial pressue of O₂ (pO₂) and CO₂ (pCO₂) saturated O₂ (sO₂), pH, HCO₃, tot...

Journal: :The American journal of physiology 1998
P Lax S Zamora J A Madrid

Exercise is recognized to affect circadian rhythmicity in a variety of ways. It masks the expression of other behavioral and physiological rhythms, entrains the master pacemaker, and influences the free-running period of other rhythms. In this paper we study the influence of exercise on the organization of the timing system by analyzing the effect of voluntary locomotor activity on the circadia...

Journal: :The Journal of heredity 2010
Derrick L Nehrenberg Shiliang Wang Robert M Hannon Theodore Garland Daniel Pomp

Exercise improves many aspects of human health, yet many people remain inactive even when exercise is prescribed. We previously created a backcross (BC) between mice selectively bred for high levels of voluntary wheel running (VWR) and fixed for "mini muscle" (MM), a recessive mutation causing approximately 50% reduction in triceps surae mass. We previously showed that BC mice having the MM tra...

2015
Tayler D. Sheahan Bryan A. Copits Judith P. Golden Robert W. Gereau David D McKemy

Both clinical and animal studies suggest that exercise may be an effective way to manage inflammatory and neuropathic pain conditions. However, existing animal studies commonly use forced exercise paradigms that incorporate varying degrees of stress, which itself can elicit analgesia, and thus may complicate the interpretation of the effects of exercise on pain. We investigated the analgesic po...

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