Epithelial-to-Mesenchymal Transition (EMT) plays a key role in epithelial-cancer. The state trajectory of its underlying Gene Regulatory Network (GRN) includes three fixed-point attractors characterizing epithelial, senescent, and mesenchymal, cell phenotypes, which implies specific cell-to-cell cell-to-tissue interactions. interplay between the GRN driving EMT one regulating Mammalian Cell Cyc...

New drug targets, markers of disease prognosis, and more efficient treatment options are an unmet clinical need in breast cancer (BC). We have conducted a pilot study including patients with luminal B stage IIA–IIIB. The presence frequency various populations stem cells (CSC) somatic were assessed the blood, tumor tissue, normal tissue. Our results suggest that BC can be divided into two distin...

Abstract Sub-Acute Ruminal Acidosis (SARA) is a metabolic disorder in dairy cattle characterized by lowered ruminal pH, as result of high grain diets. Dairy cows experiencing SARA show decreased milk production and impaired health; thus, has major economic impacts. been associated with changes the rumen epithelial microbiota. Previously, we performed meta-transcriptome sequencing on biopsy samp...

Mature Angus steers were intraruminally infused with base to increase ruminal pH. Base infusions, increasing rumen pH from 5.8 to 6.2, did not change duodenal pH but tended to reduce fecal pH. Increased ruminal pH tended to increase digestion of fiber (9 percent) but reduced ruminal digestion of starch by 18 percent (P> .05). Ruminal pH and ruminal starch digestion were negatively correlated (P...

To determine the effects of different sources of fiber and feeding frequency on digesta water-holding capacity (WHC; g H2O/g DM) and ruminal liquid contents, four ruminally fistulated Jersey steers were fed a 60:40 roughage-concentrate diet at 1.5 times NEm. Diets contained either sorghum silage (SS) or a 67:33 mixture of SS and soyhulls (SH) as roughage and were fed either once or 12 times dai...