نتایج جستجو برای: rs9939609 polymorphism

تعداد نتایج: 107470  

Journal: :Human molecular genetics 2014
Qibin Qi Tuomas O Kilpeläinen Mary K Downer Toshiko Tanaka Caren E Smith Ivonne Sluijs Emily Sonestedt Audrey Y Chu Frida Renström Xiaochen Lin Lars H Ängquist Jinyan Huang Zhonghua Liu Yanping Li Muhammad Asif Ali Min Xu Tarunveer Singh Ahluwalia Jolanda M A Boer Peng Chen Makoto Daimon Johan Eriksson Markus Perola Yechiel Friedlander Yu-Tang Gao Denise H M Heppe John W Holloway Denise K Houston Stavroula Kanoni Yu-Mi Kim Maarit A Laaksonen Tiina Jääskeläinen Nanette R Lee Terho Lehtimäki Rozenn N Lemaitre Wei Lu Robert N Luben Ani Manichaikul Satu Männistö Pedro Marques-Vidal Keri L Monda Julius S Ngwa Louis Perusse Frank J A van Rooij Yong-Bing Xiang Wanqing Wen Mary K Wojczynski Jingwen Zhu Ingrid B Borecki Claude Bouchard Qiuyin Cai Cyrus Cooper George V Dedoussis Panos Deloukas Luigi Ferrucci Nita G Forouhi Torben Hansen Lene Christiansen Albert Hofman Ingegerd Johansson Torben Jørgensen Shigeru Karasawa Kay-Tee Khaw Mi-Kyung Kim Kati Kristiansson Huaixing Li Xu Lin Yongmei Liu Kurt K Lohman Jirong Long Vera Mikkilä Dariush Mozaffarian Kari North Oluf Pedersen Olli Raitakari Harri Rissanen Jaakko Tuomilehto Yvonne T van der Schouw André G Uitterlinden M Carola Zillikens Oscar H Franco E Shyong Tai Xiao Ou Shu David S Siscovick Ulla Toft W M Monique Verschuren Peter Vollenweider Nicholas J Wareham Jacqueline C M Witteman Wei Zheng Paul M Ridker Jae H Kang Liming Liang Majken K Jensen Gary C Curhan Louis R Pasquale David J Hunter Karen L Mohlke Matti Uusitupa L Adrienne Cupples Tuomo Rankinen Marju Orho-Melander Tao Wang Daniel I Chasman Paul W Franks Thorkild I A Sørensen Frank B Hu Ruth J F Loos Jennifer A Nettleton Lu Qi

FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data fr...

2010
Sarah J. Lewis Ali Murad Lina Chen George Davey Smith Jenny Donovan Tom Palmer Freddie Hamdy David Neal J. Athene Lane Michael Davis Angela Cox Richard M. Martin

UNLABELLED Observational studies suggest that obese men have a lower risk of incident prostate cancer, but an increased risk of advanced and fatal cancers. These observations could be due to confounding, detection bias, or a biological effect of obesity. Genetic studies are less susceptible to confounding than observational epidemiology and can suggest how associations between phenotypes (such ...

Journal: :Nutrition, metabolism, and cardiovascular diseases : NMCD 2012
D Corella P Carrasco J V Sorlí O Coltell C Ortega-Azorín M Guillén J I González C Sáiz R Estruch J M Ordovas

OBJECTIVE To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population. METHODS We studied 3 independent adult samples: a random sample (n = 1580) from the general population (GP), obese hospital patients (OHP) (n = 203) and elderly...

2011
Esther Zimmermann Kristin Skogstrand David M. Hougaard Arne Astrup Torben Hansen Oluf Pedersen Thorkild I. A. Sørensen Tine Jess

BACKGROUND A recent study reported that the fatness associated A-allele of FTO rs9939609 increased plasma high sensitivity C-reactive protein (hs-CRP) levels independent of fatness. We aimed to investigate if this gene variant had fatness-independent effects on plasma hs-CRP and 10 additional circulating obesity-related adipokines throughout a broad range of body mass index (BMI) among Danish m...

Background: The heterogeneous breast cancer is the most common cause of cancer-related mortality. Obesity defined by BMI is known as a major risk factor for breast cancer. Objective: The purpose of this study was to explore the role of obesity related-polymorphisms rs9939609 FTO and rs17782313 MC4R in breast cancer development. Materials and Methods: We obtained matched peripheral blood, serum ...

2013
Chibo Liu Sihua Mou Chunqin Pan

OBJECTIVE Genome-wide association studies have shown that variance in the fat mass- and obesity- associated gene (FTO) is associated with risk of obesity in Europeans and Asians. Since obesity is associated with an increased risk of cardiovascular disease (CVD), several studies have investigated the association between variant in the FTO gene and CVD risk, with inconsistent results. In this stu...

Journal: :Hormones 2015
Natalia Lazopoulou Eleana Gkioka Ioanna Ntalla Panagiota Pervanidou Alexandra-Maria Magiakou Eleftheria Roma-Giannikou George P Chrousos Ioannis Papassotiriou George Dedoussis Christina Kanaka-Gantenbein

OBJECTIVE Single nucleotide polymorphism (SNP) risk alleles of obesogenic genes, such as the fat mass and obesity-associated protein (FTO) and the melanocortin-4 receptor (MC4R) gene, have been described in both paediatrics and adult populations. The aim of this study was to investigate the combined effect of FTO and MC4R risk alleles on the obese phenotype and metabolic profile of young childr...

Journal: :Circulation. Cardiovascular genetics 2014
Jaana Gustavsson Kirsten Mehlig Karin Leander Lauren Lissner Lena Björck Annika Rosengren Fredrik Nyberg

BACKGROUND Variants in the fat mass- and obesity-associated gene (FTO) predisposing to obesity and diabetes mellitus have also been associated with cardiovascular disease. Physical activity has been suggested to attenuate the FTO effect on obesity, but it is unknown whether this is also true for cardiovascular disease. Therefore, we explored whether physical activity modifies the FTO associatio...

2015
RI Ursu C Badiu N Cucu GF Ursu I Craciunescu E Severin

The incidence of obesity especially in Romanian population is presently escalating as a major nutrition and health problem. Clinicians aided by scientists are engaged in research approaches that include heredity aspects linked with behavior, education, applied nutrition studies and clinical therapies in order to prevent, control and reverse obesity. The common goal is to identify areas of basic...

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