Histone deacetylase inhibitors such as valproic acid (VPA) and trichostatin A (TSA) were shown to exert antitumor activity. Here, the toxicity of both drugs to human neuroblastoma cell lines was investigated using MTT test, and IC50 values for both compounds were determined. Another target of this work was to evaluate the effects of both drugs on expression of cytochrome P450 (CYP) 1A1, 1B1 and...

Unscented Kalman Filter (UKF) (Julier & Uhlmann, 1997) was developed as an improvement of Extended Kalman Filter (EKF) (Grewal & Andrews, 2001) for discrete-time filtering of the nonlinear dynamic systems. Comparison between different statistical approaches on the state and parameter estimation of the dynamic systems revealed that the performance of UKF is superior to EKF in many Kalman Filter ...

A new approach for spacecraft absolute attitude estimation based on the unscented Kalman filter (UKF) is extended to relative attitude estimation and navigation. This approach for nonlinear systems has faster convergence than the approach based on the standard extended Kalman filter (EKF) even with inaccurate initial conditions in attitude estimation and navigation problems. The filter formulat...

In systems biology, experimentally measured parameters are not always available, necessitating the use of computationally based parameter estimation. In order to rely on estimated parameters, it is critical to first determine which parameters can be estimated for a given model and measurement set. This is done with parameter identifiability analysis. A kinetic model of the sucrose accumulation ...

Cells of solid malignancies generally adapt to entire lack of oxygen. Hypoxia induces the expression of several genes, which allows the cells to survive. For DNA transcription, it is necessary that DNA structure is loosened. In addition to structural characteristics of DNA, its epigenetic alterations influence a proper DNA transcription. Since histones play a key role in epigenetics, changes in...

Neuroblastoma (NBL) originates from undifferentiated cells of the sympathetic nervous system. Chemotherapy is judged to be suitable for successful treatment of this disease. Here, the influence of histone deacetylase (HDAC) inhibitor valproate (VPA) combined with DNA-damaging chemotherapeutic, ellipticine, on UKF-NB-4 and SH-SY5Y neuroblastoma cells was investigated. Treatment of these cells wi...

Non Linear State Estimation of a Multi Axis Surgical Robot Srikrishnan Ramadurai Chair of the Supervisory Committee: Professor Blake Hannaford Electrical Engineering Minimally invasive surgical robots often have cable driven power transmission mechanisms. An example is the RAVEN surgical robot developed at the Biorobotics Laboratory, University of Washington for research on robotic surgery. The...

The evolution of performance degradation has become a major obstacle to the long-life operation Solid Oxide Fuel Cell (SOFC) system. feasibility employing resistance assess State Health (SOH) is proposed and verified. In addition, real-time Unscented Kalman Filter (UKF) based SOH estimation method further eliminate disturbance calculating directly utilizing measurement electric balance model. r...

The unscented Kalman filter (UKF) is formulated for the continuous-discrete state space model. The exact moment equations are solved approximately by using the unscented transform (UT) and the measurement update is obtained by computing the normal correlation, again using the UT. In contrast to the usual treatment, the system and measurement noise sequences are included from the start and are n...