Ror is an orphan nuclear receptor. In homozygous staggerer mutant mice (Rora), a deletion within the Rora gene leads to an overexpression of inflammatory cytokines. Because inflammation and hypoxia are 2 key stimuli of ischemia-induced angiogenesis, we studied the role of Ror in this setting. Ischemia was induced by ligation of the right femoral artery in C57BL/6 Rora / and Rora mice. After 3 a...

The US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS, formerly AERS) is a database that contains information on adverse event and medication error reports submitted to the FDA. Besides those from manufacturers, reports can be submitted from health care professionals and the public. The original system was started in 1969, but since the last major revision in 1997, rep...

Neurite elongation and branching are key cellular events during brain development as they underlie the formation of a properly wired neuronal network. Here we report that the receptor tyrosine kinases Ror1 and Ror2 modulate the growth of neurites as well as their branching pattern in hippocampal neurons. Upon Ror1 or Ror2 suppression using antisense oligonucleotides or RNA interference (RNAi), ...

Spadab describes some or their business requirements and why application de\'elopmcll! methods must change in order to meet the actual and ruture demands on high quality sortw"re, The need ror and importance or all architecture that supports thc dinerent aspcet or systems de\'c1opment is stressed, Spadab will also discuss how the architecture and strategy rorms the basis ror succesrul inrormati...

This paper reports the findings from a study aimed at examining the effectiveness of shoulder rumble strips in reducing run-off-the-road (ROR) crashes on two-lane rural highways using the empirical Bayes (EB) before-and-after analysis method. Specifically, the study analyzed the effects of traffic volume, roadway geometry and paved right shoulder width on the effectiveness of shoulder rumble st...

This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia. We conducted a statistical analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) and the Canada Vigilance Adverse Reaction Database (CVARD) concerning the side effects of cholinesterase inhib...

In this paper, we analyze 2CNF formulas from the perspectives of Read-Once resolution (ROR) refutation schemes. We focus on two types of ROR refutations, viz., variable-once refutation and clause-once refutation. In the former, each variable may be used at most once in the derivation of a refutation, while in the latter, each clause may be used at most once. We show that the problem of checking...

An efficient noise reduction approach is proposed by combining Robust Outlyingness Ratio (ROR) which measures how impulse like each pixel is, with noise adaptive fuzzy switching median filter (NAFSM) and fuzzy c-means (FCM) segmentation. Based on the ROR values all the pixels are divided into four levels. Then in the coarse and fine stage introduce the NAFSM filter that optimizes the performanc...

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 sta...

Robust Ordinal Regression (ROR) supports Multiple Criteria Decision Process by considering all sets of parameters of an assumed preference model, that are compatible with preference information elicited set of parameters, respectively. In this paper, we propose an extension of ELECTRE and PROMETHEE methods to the case of the hierarchy of criteria, which was never considered before. Then, we ada...