Endothelial surface expression of P-selectin and subsequent leukocyte rolling in venules can be induced by mast cell-derived histamine and binding of thrombin to protease-activated receptor-1 (PAR1). We hypothesized that activation of endothelial PAR2 by mast cell tryptase or other proteases also contributes to inflammatory responses. Leukocyte rolling flux and rolling velocity were assessed by...

austenite is a semi-stable phase in most stainless steels that deforms to martensite under md30 and forms martensitetype ά and ε due to the deformation in the steels. since the distribution of strain induced martensite plays animportant role in achieving desired properties, the main objective of the present work is to model martensitedistribution of ά during cold rolling using finite element me...

Rolling allows leukocytes to maintain adhesion to vascular endothelium and to molecularly coated surfaces in flow chambers. Using insights from adhesive dynamics, a computational method for simulating leukocyte rolling and firm adhesion, we have developed a semianalytic model for the steady-state rolling of a leukocyte. After formation in a force-free region of the contact zone, receptor-ligand...

Leukocyte rolling along the walls of inflamed venules precedes their adhesion during inflammation. Rolling leukocytes are thought to arrest by engaging beta2 integrins following cellular activation. In vitro studies suggest that chemoattractants may instantaneously activate and arrest rolling leukocytes. However, how leukocytes stop rolling and become adherent in inflamed venules in vivo has re...

In this study, we tested the hypothesis that reducing shear rates in postcapillary venules causes CD18-dependent, selectin-independent leukocyte rolling. Intravital microscopy was used to assess shear rate-dependent leukocyte rolling in 25- to 40-microns rat mesenteric venules. Pretreatment of animals with 25 mg/kg fucoidin, a carbohydrate moiety that binds to and inhibits selectin function, es...

In order to achieve the nonsmooth surface drag reduction structure on the inner polymer coating of oil and gas pipelines and improve the efficiency of pipeline transport, a structural model of the machining robot on the pipe inner coating is established. Based on machining robot, an experimental technique is applied to research embossing and coating problems of rolling-head, and then the moldin...

We calculate the friction force acting on a hard cylinder or spherical ball rolling on a flat surface of a viscoelastic solid. The rolling-friction coefficient depends non-linearly on the normal load and the rolling velocity. For a cylinder rolling on a viscoelastic solid characterized by a single relaxation time Hunter has obtained an exact result for the rolling friction, and our result is in...

Strip tearing during cold rolling process has always been considered among the main concerns for steel companies, while several works have been done so far regarding the examination of this issue. In this paper, experimental data from cold rolling tandem mill is used for detecting strip tearing. Sensors are placed across the cold rolling tandem mill, to collect information on parameters (such a...

for helpful discussions and comments, and to Pam Dillon and Paula Drew for assistance in preparing this document. The views expressed are those of the authors and should not be attributed to the Reserve Bank of Australia.