BACKGROUND Human monocyte-derived DC (mDC) loaded with peptides, protein, tumor cell lysates, or tumor cell RNA, are being tested as vaccines against multiple human malignancies and viral infection with great promise. One of the factors that has limited more widespread use of these vaccines is the need to generate mDC in large scale. Current methods for the large-scale cultivation of mDC in sta...

Article history: Received: 08.11.2013. Received in revised form: 12.01.2013. Accepted: 14.01.2014. The grinding roller shaft is a key part of the grinding roller. It has a step-shaped shaft with different round cross-sections and 1850 mm × 1110 mm rectangular cross-section. If the general method of free forging is used, the upsetting diameter of ingot will reach 2900 mm, and 8400 t hydraulic pr...

The traction developed between a thin flexible web, wrapped around a non-vented, rotating cylindrical roller is studied experimentally and theoretically. A series of eight webs representing a wide range of surface roughness characteristics are traction-tested against the same roller over a wide speed range. A mathematical model that couples air film pressure, web deflection, and asperity deform...

Mobile devices generally have small screens. To display information that is well suited for larger screens (e.g. desktop computers), the information has to be segmented into many small presentation units that can fit into the small screen of mobile devices. This makes it difficult to effectively organize information and help users navigate to and from the information they want. This paper prese...

This study presents effects of the vane spring stiffness on frictional power characteristics of a refrigeration compressor. Comparisons on the compressor performance are investigated for different vane spring stiffnesses with compressors designed with high and low shell pressures. Results show that while compressors with a low shell pressure using a higher spring stiffness combination may reduc...

Major surgery, trauma, and infection induce a proinflammatory mediator response which, if excessive, may cause tissue injury. The response was measured during elective coronary bypass surgery when a centrifugal pump or a roller pump, differing in their basic working principles, was used for extracorporeal circulation (ECC). Eight patients were perfused with a centrifugal pump and eight patients...

Molecular dynamics simulations using tight-binding many body potential are carried out to study the roller imprint process of a gold single crystal. The effect of the roller tooth's taper angle, imprint depth, imprint temperature, and imprint direction on the imprint force, adhesion, stress distribution, and strain are investigated. A two-stage roller imprint process was obtained from an imprin...

Despite the advanced technologies of battery back-up for heart-lung consoles and the availability of system-wide generators, electromechanical failure is still occurring. Several heart-lung machine manufacturers still provide unsafe handcranking devices to use in the case of an emergency while using a roller blood pump. A new design has been engineered to eliminate safety and quality issues for...

The aim of this project was to study the influence of microneedles on transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride across porcine ear skin in vitro. Microchannel visualization studies were carried out and characterization of the microchannel depth was performed using confocal laser scanning microscopy (CLSM) to demonstrate microchannel formation following mic...

OBJECTIVE One of the major damage caused by occlusion in roller pumps is hemolysis. Comparative studies between roller pump with adjustments non occlusive and centrifugal pumps have been made in recent decades in an attempt to develop new products and adjustments that cause fewer traumas to the figurative elements of blood. Usually the roller pumps are adjusted by the static method due to conce...