Coumatetralyl (Racumin ) has been known since 1957 as a multiple dose anticoagulant and has been used successfully over many decades. In the seventies and especially the eighties, rats developed an increased resistance to anticoagulants in certain regions of Central Europe. Also, the addition of vitamin K to animal feed (especially to chicken feed) has reduced the efficacy against rats and mice...

Good Laboratory Practice (GLP) guidelines were implemented by the U.S. Environmental Protection Agency in August 1989. The purpose of the standards are to ensure the integrity of laboratory and field studies which are conducted in support of FIFRA permits and pesticide registrations. Since the advent of GLP requirements, the cost of conducting field trials has increased 40 to 200%, depending up...

b a ckground: zoonotic cutaneous leishmaniasis is a growing health problem in many rural areas of iran. rhombo mys opimus , the great gerbil, is the main animal reservoir of zcl in the northeast and central part of iran. the aim of the current study was to evaluate the rodenticidal effect of coumavec® (a mixture of coumatetralyl 0.5% and etofenprox 0.5%) on r. opimus under laboratory condition....

background: zoonotic   cutaneous leishmaniasis (zcl) is an increasing health problems in many rural areas of iran. the aim of this study was to introduce a new alternative rodenticide to control the reservoirs of zcl, its effect on the vector density and the incidence of the disease in hyperendemic focus of esfa­han county, central iran. methods: the study was carried out from january 2011 to j...