BACKGROUND Therapeutic targeting of Rho-Associated, Coiled-Coil Containing Protein Kinase (ROCK) signaling for tumor cells and tumor endothelium has shown efficacy in pre-clinical tumors models, and a better understanding of how proteins regulate tumor progression will strengthen our knowledge over disease etiology and treatment of patients with cancer. Recent reports have shown that ROCK activ...

Understanding how geophysical and hydrologic properties are related is a key problem in hydrogeophysical data fusion. Traditionally this link has been made by rock physics investigations that define how pore-scale variations in properties like mineralogy, fluid content, and grain geometry affect the geophysical response of a rock or sediment. As the scale of investigation increases from the lab...

Cancer-associated changes in cellular behavior, such as modified cell-cell contact, increased migratory potential, and generation of cellular force, all require alteration of the cytoskeleton. Two homologous mammalian serine/threonine kinases, Rho-associated protein kinases (ROCK I and II), are key regulators of the actin cytoskeleton acting downstream of the small GTPase Rho. ROCK is associate...

In 3-D analyses of rock slopes there’re can be numerous sliding paths a long a coplanar nonpersistent discontinuity with a known strike. This paper describes an approach for the determination of a most probable sliding path. For this particular study, several blocks of gypsum with the dimensions of 15×15×15 cm containing coplanar non-persistent open joints were fabricated. The models have vario...

The mechanical properties of any substance are essential facts to understand its behaviour and make the maximum use of the particular substance. Rocks are indeed an important substance, as they are of significant use in the energy industry, specifically for fossil fuels and geothermal energy. Attenuation of seismic waves is a non-destructive technique to investigate mechanical properties of res...

Permeability is the ability of porous rock to transmit fluids and one of the most important properties of reservoir rock because oil production depends on the permeability of reservoirs. Permeability is determined using a variety of methods which are usually expensive and time consuming. Reservoir rock properties with image analysis and intelligent systems has been used to reduce time and money...

35 36 The rock type of hard-substrata marine habitats can affect numerous benthic invertebrates, but 37 little is known of the effects on molluscan assemblages, for example, the chitons often found 38 under intertidal boulders. We compared chiton assemblage composition, abundance, species 39 richness, and patterns of frequency distribution in ten boulder-fields containing either hard 40 metamor...

Abstract Acoustic emission (AE) signals contain substantial information about the internal fracture characteristics of rocks and are useful for revealing laws governing release energy stored therein. Reported here is evolution rock failure with different master crack types as investigated using Brazilian splitting tests (BSTs), direct shear (DSTs), uniaxial compression (UCTs). The AE parameters...

Sound signals generated during rock failure contain useful information about crack development. A sound-signal-based identification method for types is proposed. In this method, the sound of tensile cracks, using Brazilian splitting test, and those shear direct are collected to establish training samples. The spectrogram used characterize signal taken as input. To solve small sample problem, si...