Performance of structures during recent earthquakes shows that the effect of vertical component of earthquake (VCE) could be considered as one of the main causes of bridges collapse. In most of bridge design codes, for seismic analysis of bridges, VCE is not taken into account or a distinguished method isn’t presented for assessment of VCE. In the present work, the effect of VCE on two existing...

This paper aims to reveal the mechanical properties, energy evolution characteristics, and dynamic rupture process of preflawed granite under impact loading with different rock bridge angles strain rates. A series experiments were conducted along separate Hopkinson press bar (SHPB) testing system analyze study overall fracture process. Under load, peak stress increases increase angle rate, but ...

Original scientific paper Rock burst is a common serious geological hazard in underground engineering, which seriously affects the progress of projects. The mechanism of rock burst can be explained by the distribution law of rock fragments and its fractal characteristics. A simulation experiment of rock burst was conducted with the granite samples under a biaxial loading machine system to analy...

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion diseases. We found that overactivation of ROCK signaling occurred in neuronal s...

1 Department of Endocrinology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA, 2 GIM Foundation, Little Rock, AR, USA, 3 Department of Internal Medicine and Hospital Medicine, Christus Trinity Mother Frances Hospital, Tyler, TX, USA, 4 Department of Policy, University of Arkansas for Little Rock, Little Rock, AR, USA, 5 Tutwiler Clinic, Tutwiler, MS, USA...

1 SB Ankara Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, 7. Göğüs Hastalıkları Kliniği, Ankara, 2 Afyon Kocatepe Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Afyonkarahisar, 3 SB Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Evde Bakım ve Solunum Rehabilitasyon Ünitesi, Ankara, 4 SB Ankara Atatürk Göğüs Hastalıkları...

This paper deals with the statistical analysis of the uniaxial compressive strength and of the elastic modulus of jointed rock masses under different confining pressures. Properties of the rock masses with different joint fabric, with and without gouge have been considered in the analysis. A large amount of experimental data of jointed rock masses from the literature has been compiled and used ...

Background: Negative regulatory mechanisms of ROCK signaling are poorly understood. We have discovered a novel mechanism to attenuate ROCK signaling. Results: Coronin1B is a novel binding partner of ROCK2 that inhibits ROCK signaling to myosin. Conclusion: Coronin1B regulates ROCK by a novel signal attenuation mechanism. Significance: Coronin1B attenuation of ROCK signaling is associated with N...

Rock bolts have been widely used as rock reinforcing members in underground coal mine roadways and tunnels. Failures of rock bolts occur as a result of overloading, corrosion, seismic burst and bad grouting, leading to catastrophic economic and personnel losses. Monitoring the health condition of the rock bolts plays an important role in ensuring the safe operation of underground mines. This wo...