While the responses of Tien Shan glaciers--and glaciers elsewhere--to climatic changes are becoming increasingly well understood, this is less the case for permafrost in general and for rock glaciers in particular. We use a novel approach to describe the climate sensitivity of rock glaciers and to reconstruct periods of high and low rock glacier activity in the Tien Shan since 1895. Using more ...

Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and inadequate capacity to block detrimental rt-PA activity in brain endothelial cells (BECs), selecti...

This research work presents a case study of rock mass characterization on diversion tunnels at Diamer Basha Dam, Pakistan. Geological and geotechnical studies were performed to characterize the rock mass along the axis of diversion tunnel. The core specimens retrieved were tested in laboratory and physical and mechanical properties of the rock mass were determined. Detailed discontinuity survey...

In underground tunnels or caverns, time-dependent deformation or failure of rock mass, such as extending cracks, gradual rock falls, etc., are a costly irritant and a major safety concern if the time-dependent damage of surrounding rock is serious. To understand the damage evolution of rock mass in underground engineering, an in situ experimental testing was carried out in a large belowground t...

Original scientific paper Rock generally contains various micro-cracks, fissures, pores, joints, and other defects. These defects affect the mechanical properties of rock. In order to clarify the influence of native fissures on rock deformation and failure modes, a laboratory study was carried out using the fissured dolomite, and acoustic wave velocity measurement and natural water absorption t...

Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and due to VSMCs phenotype change. ADMA activates Rho/ROCK signal pathway that interpreted by the eleva...

rndetermination of rock mass deformation modulus is very important in different projects, especially in civil and mining engineering works. in-situ measurements such as dilatometer, plate load and flat jack methods may be applied to determine the deformation modulus. however, these methods are very expensive and time- consuming. analytical methods are very useful approaches which can also be us...

Rock abrasiveness is ability of rock to wear down the working tool during the mutual interaction between the working indentor and the rock in the mechanical rock cutting process. The cutting indentor is worn down during the interaction, which changes its geometric dimensions causing the enlargement of a contact area between the tool and the rock surface. The changes in these dimensions conseque...

In this paper we present a stereo feature-based method using SIFT (Scale-invariant feature transform) descriptors. We use automatic feature extractors, matching algorithms between images and techniques of robust estimation to produce a DTM (Digital Terrain Model) using convergent shots of a rock glacier.The geomorphologic structure observed in this study is the Veleta rock glacier (Sierra Nevad...