Background The use of biomarkers for diagnosis of Preeclampsia (PE), a life-threatening pregnancy disorder, could reduce serious complications of this disease. In this study, we investigated dysregulation of endoglin (Eng) expression and diagnostic accuracy of soluble endoglin (sEng) in PE patients. Methods For this case-control study, 26 mild and 15 severe preeclamptic women along with 20 no...

To identify mutations that cause hereditary hemorrhagic telangiectasia (HHT, or Rendu-Osler-Weber syndrome), clinical evaluations and genetic studies were performed on 32 families. Linkage studies in four of eight families indicated an endoglin (ENG) gene mutation. ENG sequences of affected members of the four linked families and probands from the 24 small families were screened for mutations, ...

The solution to the canonical problem of a radiating infinitesimal electric dipole antenna that is centred in a multilayered, concentric metamaterial-based spherical shell system is presented. It is demonstrated that when this system is electrically small, a specifically designed homogenous and isotropic epsilon-negative (ENG) layer can function as a distributed matching element to the antenna ...

OBJECTIVE To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, migration, and ability to form capillary-like tubes. Endothelial cells deriv...

Endoglin (ENG), an ancillary receptor for several members of the transforming growth factor (TGF)-beta superfamily, has a well-studied role in endothelial function. Here, we report that endoglin also plays an important role early in development at the level of the hemangioblast, an embryonic progenitor of the hematopoietic and endothelial lineages. Eng(-/-), Eng(+/-) and Eng(+/+) mouse embryoni...

BACKGROUND Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage maturation and implicated in the control of fibrosis, angiogenesis and inflammation. METHODS Endoglin expression was monitored over 14 days after ...

BACKGROUND AND PURPOSE Endoglin deficiency causes hereditary hemorrhagic telangiectasia-1 and impairs myocardial repair. Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia-1 are associated with a high incidence of paradoxical embolism in the cerebral circulation and ischemic brain injury. We hypothesized that endoglin deficiency impairs stroke recovery....

There are many kinds of public transportation systems, e.g. Xue-shan tunnel, high-speed railway, and airport shuttle are developed in Taiwan recently. The risk hidden in the space of long road tunnel could cause serious life loses and transportation system damage. Therefore, how to prevent and decrease the impact of disaster should be considered for the disaster precaution and security manageme...

Study of indoor air quality (IAQ) has received attention of the researchers and policy makers over the last several years due to its affiliation with the adverse health effects and occupants’ discomfort. This article focuses on the importance and need of IAQ studies in Indian rural and urban indoor environments. A number of questions in this context are posed and addressed, together with identi...