PURPOSE Most hormone receptor (HR)(+)/HER2(-) breast cancer patients respond unfavorably to neoadjuvant chemotherapy (NAC); however, genomic tests may identify those patients who are likely to benefit. Using the Prosigna assay, we first evaluated the technical performance of core needle biopsy (CNB) tissues. We then determined whether Prosigna risk of relapse (ROR) score and intrinsic subtype p...

OBJECTIVES Data mining algorithms have been developed for the quantitative detection of drug-associated adverse events (signals) from a large database on spontaneously reported adverse events. In the present study, the commonality of signals detected by 4 commonly used data mining algorithms was examined. METHODS A total of 2,231,029 reports were retrieved from the public release of the US Fo...

-Impulse noise detection is a critical issue when removing impulse noise and impulse/gaussian mixed noise. The framework combines Robust Outlyingness Ratio (ROR) detection mechanism and Fuzzy C Means (FCM) clustering algorithm and Nonlocal Means (NLM) filter. ROR for measuring how impulse like each pixel is and then all pixels are divided into four clusters according to the ROR values. The dete...

The re la tion be tween chips, bits and frames er ror rates in the Ad di tive White Gaussi an Noise (AWGN) chan nel for a Di rect Se quence Spread Spec trum (DSSS) sys tem, in Mul ti ple Ac cess In ter fer ence (MAI) con di tions is eval u ated. A sim ple er ror-correction code (ECC ) for the Frame Er ror Rate (FER) eval u a tion is used. 64 bits (chips) Pseudo Noise (PN) se quences are em ploy...

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan receptors because their ligands were unknown. They are now known to contain functional extracellular Wnt-binding domains and are implicated in Wnt-signal transduction in multiple species. Although their signaling mechanisms still remain to be resolved in detail, both Ryk and Ror control important developme...