نتایج جستجو برای: rifampicin
تعداد نتایج: 5438 فیلتر نتایج به سال:
1 Boriello SP, Jones RH, Phillips I. Rifampicin-associated pseudomembranous colitis. Br Med J 1980; 281:1180 2 Fournier C, Orgiazzi J, Lenoir B, Dechavanne M. Pseudomembranous colitis probably due to rifampicin. Lancet 1980; 1:101 3 Melange M, Vanheuverzwyn B, Fiasse R. Pseudomembranous colitis and rifampicin. Lancet 1980; II: 1192 4 Moriarty HJ, Scobie BA. Pseudomembranous colitis in a patient...
Naveh, Y., and Friedman, A. (1973). Archives of Disease in Childhood, 48, 967. Rifampicin therapy in Gram-negative bacteraemia in infancy. Rifampicin was given to 3 severely ill infants suffering from septicaemia due to klebsiella, Shigella flexneri, and Esch. coli, after numerous other antibiotics had proved ineffective. Rifampicin proved to be rapidly effective. No untoward side effects were ...
The aim of this study was to assess the frequency of gastrointestinal side effects (GSE) and hepatotoxicity in patients treated with rifampicin for an osteoarticular infection and to determine if there is an association between rifampicin plasma concentrations and side effects. Rifampicin plasma concentrations were prospectively measured before (trough concentration, C(0)) and 2 +/- 0.5 h (peak...
BACKGROUND Tuberculosis is the world's leading infectious disease killer. We aimed to identify shorter, safer drug regimens for the treatment of tuberculosis. METHODS We did a randomised controlled, open-label trial with a multi-arm, multi-stage design. The trial was done in seven sites in South Africa and Tanzania, including hospitals, health centres, and clinical trial centres. Patients wit...
A comparative pharmacokinetic study of Lositril (rifampicin) was carried out in six multibacillary and twelve paucibacillary leprosy cases. The type of leprosy had no significant effect on rifampicin pharmacokinetics. The effect of dapsone and clofazimine when given separately and in combination was studied on rifampicin pharmacokinetics in each group of six patients. Within group comparison re...
Therapeutic Drug Monitoring (TDM) is a routinely practised clinical laboratory technique which aids the clinicians with a clear clinical judgement of the drug therapy and optimize the doses if necessary. Rifampicin is the most important and potent component of first line therapy of tuberculosis (TB). Several factors like age, weight, gender, doses and formulations, gastro-intestinal disorders, ...
Rifampicin, a semisynthetic antibiotic, is known to inhibit the bacterial DNA-dependent RNA polymerase (1), the growth of some animal viruses (2), and the focus formation induced by oncogenic viruses (3, 4). While certain derivatives of rifampicin can inhibit the RNA-dependent DNA polymerase activity of oncogenic viruses, and a similar activity found in normal and virus-transformed cells (5-7),...
We evaluated the effectiveness and safety of rifampicin addition to clarithromycin in the treatment of Legionnaires' disease. An observational cohort study was conducted on patients assigned to a Legionnaires' disease outbreak. Of 32 patients with confirmed Legionella pneumonia, 11 received clarithromycin monotherapy and 21 received combination therapy of clarithromycin with rifampicin. Both gr...
A 47-year-old man diagnosed with pulmonary tuberculosis was referred to our hospital. Rifampicin, isoniazid, pyrazinamide and ethambutol were administered, and the patient's symptoms promptly improved. On the 19th hospital day, he developed acute kidney injury with a fever and chills. Renal biopsy specimens indicated tubulointerstitial nephritis. Suspecting rifampicin-induced acute kidney injur...
Background Tuberculosis (TB) complicating HIV-1 infection is a persistent significant clinical concern, particularly in resource limited settings. Treatment of HIV-infected patients with TB often comprises efavirenz-containing antiretroviral regimens particularly when on TB treatment containing rifampicin. Although rifampicin may reduce EFV concentrations, little is known of the effect of the H...
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