Allergic rhino-conjunctivitis and asthma are induced by sensitization to one or more allergens in susceptible individuals. Specific immunotherapy (SIT) is indicated in allergic diseases, because it modulates the immune response inducing peripheral T-cell tolerance and activation of regulatory T-cells. On this basis, SIT is considered the only therapeutic approach that can modify the natural his...

piRNAs guide PIWI proteins to silence transposons in animal germ cells. In Drosophila, the heterochromatic piRNA clusters transcribe piRNA precursors to be transported into nuage, a perinuclear structure for piRNA production and transposon silencing. At nuage, reciprocal cycles of piRNA-directed RNA cleavage—catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3) in Drosophila—dest...

Ulcerative oral and skin lesions have become an issue of concern for the health of the managed black rhinoceros (rhino) (Diceros bicornis) populations. Lesions exhibited by the black rhino are clinically similar to those observed in other species with superficial necrolytic dermatitis (SND). One biochemical alteration in dogs with SND is severe hypoaminoacidemia, and nearly all cases are fatal....

OBJECTIVES Overutilisation of antibiotics may contribute to the emergence of antimicrobial drug resistance, a growing international concern. This study aimed to analyse the performance of UK general practices with respect to antibiotic prescribing for respiratory tract infections (RTIs) among young and middle-aged adults. SETTING Data are reported for 568 UK general practices contributing to ...

Der Vortrag berichtet über Erfahrungen aus der modularen, mehrere Geschäftsfelder im Commerzbank-Konzern überspannenden Produktentwicklung. Grundpfeiler sind dabei einheitliche Prozesse und Prozessverantwortung als Bindeglied für die übergreifende Entwicklung sowie eine service-orientierte Architektur als Basis für webserviceorientierte Vertriebssysteme. Vita Christian Rhino (Jahrgang 1969) ist...

PURPOSE To report a case of bilateral ophthalmic artery occlusion in rhino-orbito-cerebral mucormycosis. METHODS Reviewed clinical charts, photographs, and fluorescein angiography RESULTS An 89-year-old man with poorly controlled diabetes developed sudden bilateral ptosis, complete ophthalmoplegia of the right eye, and superior rectus palsy of the left eye. Brain and orbit magnetic resonanc...

Mucormycosis is an uncommon acute invasive fungal infection that affects immunocompromised patients. It progresses rapidly and has poor prognosis if diagnosed late. Early detection, control of the underlying condition with aggressive surgical debridement, administration of systemic and local antifungal therapies, hyperbaric oxygen as adjunctive treatment improves prognosis and survivability.

Introduction: Chronic rhino-sinusitis defined as inflammation of the nose and paranasal sinuses. Functional endoscopic sinus surgery (FESS) has now become a well-established strategy for chronic rhinosinusitis refractory to medical

background: nosocomial rhino sinusitis causes major problems in all intensive care units (icus). objective: to describe incidence, epidemiologic, clinical manifestations, and microbiologic findings in icus admitted cases with nosocomial sinusitis. materials and methods: a prospective, cross sectional study done in pediatric & adult icus in rasoul akram hospital; tehran iran (2007-2008). para-na...