نتایج جستجو برای: rheumatoid factors
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BACKGROUND Treatment with disease-modifying anti-rheumatic drugs (DMARDs) has raised concerns about the risk of malignancies in rheumatoid arthritis (RA) patients. However, the association between biologic DMARDs (bDMARDs) and malignancy in previous reports remains controversial. Therefore we aimed to estimate the incidence of malignancy in early RA patients and to evaluate the relative risk of...
INTRODUCTION Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients. METHODS Using computed tomography, coronary artery calcification was measured in 195 men and women with rheumatoid arthritis aged 45 to 84 years without clinical cardiovascular disease and compared with ...
Background and purpose: Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the wrist. The aim of this study was to assess the prevalence of CTS and the risk factors associated with this condition. Materials and methods: A cross-sectional study was conducted in Sari, Iran 2014-2016, among patients with clinical symptoms in whom CTS was confirmed by electrodiagnostic tes...
The existence of agglutinating substances reactive with autologous and isologous human gamma globulin (yG) has been recognized for some time. These substances were first found in patients with rheumatoid arthritis and were consequently termed "rheumatoid factor" (RF). It is now clear that rheumatoid factor is not specific for rheumatoid arthritis, but occurs in individuals with a wide variety o...
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific skin lesions of RA such as rheumatoid nodules, exacerbated nodules, rheumatoid vascu...
Rheumatoid factors (RF) associated with arthritic joint erosion are only seen transiently, if at all, in nondiseased individuals. Therefore, a tolerance mechanism must exist that prevents pathologic RF B cells from expressing Abs. Surprisingly, it has been shown that pathologic RF B cells are not tolerized by any previously established tolerance mechanism such as deletion, receptor editing, ane...
OBJECTIVE To determine the population incidence of juvenile rheumatoid arthritis (JRA) in Quebec. METHODS We obtained data from Quebec's physician claims database. Incident cases were defined as having a visit for JRA in 2000, no visit in the previous 3 years, a confirmed diagnosis by an arthritis specialist, or having >/= 2 visits to any physician for JRA, >/= 2 months apart but within 2 yea...
Still's disease (juvenile chronic polyarthritis) differs markedly from adult rheumatoid arthritis in the relative incidence of rheumatoid factor. The sheep cell agglutination test was found to be positive in only 11 to 13 per cent. of Still's disease patients compared with 70 to 80 per cent. of affected adults (Bywaters, Carter, and Scott, 1959; Laaksonen, 1966). Similarly, using the sensitive ...
BACKGROUND Rheumatoid arthritis patients are at higher risk of developing comorbidities. The main objective of this study was to evaluate the prevalence of major comorbidities in Chinese rheumatoid arthritis patients. We also aimed to identify factors associated with these comorbidities. METHODS Baseline demographic, clinical characteristics and comorbidity data from RA patients enrolled in t...
Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. The presence of rheumatoid factors is currently used as a marker for RA. However, rheumatoid factors have modest specificity (~70%) for the disease. In recent years, several ...
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