Adders and multipliers are two main units of the computer arithmetic processors and play an important role in reversible computations. The binary multiplier consists of two main parts, the partial products generation circuit (PPGC) and the reversible parallel adders (RPA). This paper introduces a novel reversible 4×4 multiplier circuit that is based on an advanced PPGC with Peres gates only. Ag...

Cultured extrahepatic cells possess a specific high affinity receptor for high density lipoprotein (HDL) that is induced by cholesterol delivery to cells. Current results suggest that HDL receptors on cultured human fibroblasts and mouse peritoneal macrophages promote reversible binding of HDL to the cell surface without internalization of lipoprotein particles. When 125I-HDL3 was bound to cult...

reversible logic circuits have found emerging attentions in nanotechnology,optical computing, quantum computing and low power design. a programmablelogic array (pla) is a universal circuit which is used to implement combinationallogic circuits. the main part of a pla is its and array. in this study we propose twotypes of optimized reversible programmable logic array (rpla) circuits. the firstty...

Peptide binding by class II major histocompatibility complex proteins is generally enhanced at low pH in the range of hydrogen ion concentrations found in the endosomal compartments of antigen-presenting cells. We and others have proposed that class II molecules undergo a reversible conformational change at low pH that is associated with enhanced peptide loading. However, no one has previously ...

While much work has been devoted to nanoscale assembly of functional materials, selective reversible assembly of components in the nanoscale pattern at selective sites has received much less attention. Exerting such a reversible control of the assembly process will make it possible to fine-tune the functional properties of the assembly and to realize more complex designs. Herein, by taking adva...

Several approaches have been used to identify the factors involved in mRNA splicing. None of them, however, comprises a straightforward reversible method for inhibiting the second step of splicing using an external reagent other than a chelator. This investigation demonstrates that the addition of boric acid to an in vitro pre-mRNA splicing reaction causes a dose-dependent reversible inhibition...

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Although closely related, these enzymes display very different substrate specificities that only partially overlap. This disparity is largely due to differences in the number of aromatic residues lining the active site...

Nature has used transition-metal ions with unpaired d-electrons to overcome the kinetic inertness of O2 and to control its thermodynamic tendency towards reduction. High-resolution X-ray crystal structures of O2-carrying proteins show that Nature has devised three distinct solutions to the problem of reversible O2 binding. The three types can be classified according to their active sites: Hb (h...

A technique has been developed to investigate [3H]sulpiride binding in rat brain sections using quantitative autoradiography and tritium-sensitive film. Binding was saturable and reversible with very low nonspecific binding. [3H]Sulpiride bound to an apparent single population of sites in striatum with a Kd of 3.2 nM and Bmax of 447 fmol/mg protein. Binding sites were localized in the lamina gl...

Binding of aminocyclitol antibiotics to intestinal and kidney brush border membranes has been studied in vitro by means of vesicular preparations. The binding is rapid, reversible, specific, saturable and has a high affinity. To both tissues, gentamicin and sisomicin bind to a single binding site or receptor. These antibiotics demonstrate increased binding under conditions of increasing pH. Mem...