Autonomic neuropathy has numerous causes, some of them common, such as diabetic autonomic neuropathy, and others rare, such as Fabry disease, but all can produce disabling symptoms. Autonomic neuropathy can affect the sympathetic, parasympathetic, and enteric branches of the autonomic nervous system to variable degrees, causing dysfunction of different organs such as heart, intestinal tract, an...

After surgical correction of esophageal atresia with or without tracheoesophageal fistula, esophageal body motility dysfunction has been reported in nearly all patients. Using high-resolution esophageal manometry before surgical repair in 2 children with isolated tracheoesophageal fistula, we sought to determine whether dysmotility was present before any surgical insult to test the hypothesis t...

The concept of intestinal failure (IF) is currently defined as a critical reduction of functional gut mass below the minimum amount necessary for adequate digestion and absorption to satisfy body nutrient and fluid requirements for growth in children or maintenance in adults. Causes of IF include intestinal hypomotility disorders, intestinal mucosal disorders, and the short bowel syndrome. We p...

The results allow proposing a novel hypothesis and concept of cholesterol gallstone pathogenesis in man: cholestanol may be responsible for the cholesterol supersaturation of gallbladder bile, aseptic inflammation of the gallbladder mucus and consecutive hypersecretion of glycoprotein mucin, gallbladder hypomotility as well as for the heterogenic nucleation process and precipitation of choleste...

BACKGROUND We have demonstrated that anorexia nervosa is underpinned by overwhelming adrenal sympathetic activity which abolishes the neural sympathetic branch of the peripheral autonomic nervous system. This physiological disorder is responsible for gastrointestinal hypomotility, hyperglycemia, raised systolic blood pressure, raised heart rate, and other neuroendocrine disorders. Therefore, we...

Exogenous fibrolytic enzymes (EFE) and yeast are feed supplements that improve forage digestion in rumen, but their influences on physical reticulorumen parameters not well studied. This study was designed to evaluate the effect of EFE:endo-β-xylanase (37x104 U/cow/day), endocellulase (45x104 endo-β-glucanase (12x104U/cow/day), active - Saccharomyces cerevisiae CNCM-1077 (10x109CFU/cow/day) pH ...