UNLABELLED PET is an important functional imaging technique that can be used to investigate neurotransmitter receptors and transporters directly by mapping human brain function. PET is increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia. METHODS This review focuses on the use of PET tracers and kinetic modeling in identifying r...

Cardiovascular disease is associated with high morbidity, mortality, and financial burden to healthcare services.1–3 In the United States, cardiovascular disease is the leading cause of death in both men and women, accounting for 1 in every 2.9 deaths in 2006, with coronary disease accounting for 1 in every 6 deaths.2 Noninvasive cardiac imaging increasingly plays a fundamental role in diagnosi...

Cardiovascular disease is associated with high morbidity, mortality, and financial burden to healthcare services.1–3 In the United States, cardiovascular disease is the leading cause of death in both men and women, accounting for 1 in every 2.9 deaths in 2006, with coronary disease accounting for 1 in every 6 deaths.2 Noninvasive cardiac imaging increasingly plays a fundamental role in diagnosi...

Several new tracers are being developed for use with PET to assess pathways that are altered in cancers, including energy use, cellular signaling, transport, and proliferation. Because increased proliferation is a hallmark of many cancers, several tracers have been tested to track the DNA synthesis pathway. Thymidine, which is incorporated into DNA but not RNA, has been used in laboratory studi...

UNLABELLED BACKGROUND The characterization of fast-decaying radiotracers that are labeled with carbon-11 (t1/2 = 20.38 min), including critical measurement of specific radioactivity (activity per mole at a specific time) before release for use in positron-emission tomography (PET), has relied heavily on chromatographic plus radiometric measurements, each of which may be vulnerable to signifi...

UNLABELLED Whole-body PET/CT was used to characterize the radiation dosimetry of (11)C-DPA-713, a specific PET ligand for the assessment of translocator protein. METHODS Six healthy control subjects, 3 men and 3 women, underwent whole-body dynamic PET scans after bolus injection of (11)C-DPA-713. Subjects were scanned from head to mid thigh with 7 passes performed, with a total PET acquisitio...

Although numerous anticancer drugs are widely used in the clinic, many questions remain about pharmacokinetics, biodistribution, toxicities, and efficacy. Positron emission tomography (PET) using radiolabeled drugs is a promising method to further understand the clinical behavior of anticancer agents. In addition, it may contribute to better guided treatment planning in individual patients with...

A number of years ago, [Bro05] explored a prospective language feature then known as Object Templates. That feature died on the vine due to healthy skepticism voiced by EWG, as well as the usual lack of cycles to develop the idea much further. However, the original underlying issue is still present in C++11, after even many additional years of experimental effort to achieve the desired effect v...

C++ is the most commonly used language in introductory and intermediate programming courses in many universities. This language had its rapid development in recent years. Its abstractions are more flexible and affordable than ever before. There are so many new features in the new standard, known as C++11, that it may be considered a new language. All these changes should find their place in tea...

PURPOSE To evaluate the accuracy and biological basis for [(11)C]choline-PET-CT in the nodal staging of high risk localized prostate cancer patients. EXPERIMENTAL DESIGN Twenty-eight patients underwent dynamic [(11)C]choline-PET-CT of the pelvis and lower abdomen prior to extended laparoscopic pelvic lymph node dissection (eLPL). The sensitivity and specificity of [(11)C]choline PET, [(11)C]c...