نتایج جستجو برای: residual resistance factor
تعداد نتایج: 1269252 فیلتر نتایج به سال:
Overcoming imatinib mesylate (IM) resistance and disease persistence in patients with chronic myeloid leukemia (CML) is of considerable importance to the issue of potential cure. Here we asked whether autocrine signaling contributes to survival of BCR/ABL+ cells in the presence of IM and nilotinib (NI; AMN107), a novel, more selective Abl inhibitor. Conditioned media (CM) of IM-resistant LAMA84...
Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-sensitive lung adenocarcinoma cell lines exposed to reversible or irreversible epidermal growth factor receptor (EGFR) inhibitors, alone or in combination with ...
Abrasive wear resistance of injection molded polycarbonate (PC) and polycarbonate + zinc oxide nanocomposites containing 0.5 wt% ZnO nanoparticles was determined as a function of the sliding direction with respect to injection flow. First we have performed single scratch testing under progressively increasing the load applied. Then sliding wear testing consisting of 15 successive scratches alon...
BACKGROUND Recent studies have described genetic mutations that affect the risk of thrombosis as a result of abnormal levels of such hemostatic parameters as protein C, protein S, and the activated protein C resistance ratio. Although these mutations suggest that genes play a part in determining variability in some hemostasis-related phenotypes, the relative importance of genetic influences on ...
In the present article, the residual resistivity of some metallic elements of the periodic table is reported on the basis of model potential formalism. Ashcroft's well known empty core (EMC) model potential is explored first time with five different types of the local field correction functions proposed by Hartree (H), Taylor (T), Ichimaru-Utsumi (IU), Farid et al (F) and Sarkar et al (S) to in...
Potential output is the largest amount of products that can be produced by fully utilizing available labor and capital stock; the output gap is defined as the discrepancy between actual and potential output. If data on production factors contain measurement errors, total factor productivity (TFP) cannot be estimated accurately from the Solow residual (i.e., the portion of output that is not att...
Residual stresses in a surface layer determine many exploitation characteristics of machined surface. Depending on their kind and the type of applied loading, the influence of residual stresses can be negative or positive. Tensile residual stresses usually exert highly detrimental impact on several functional aspects such as strength, fatigue life, corrosion, wear resistance, etc., whereas comp...
KIT gain of function mutations play an important role in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of ABL, platelet-derived growth factor receptor (PDGFR), and KIT and represents a new paradigm of targeted therapy against GISTs. Here we report for the first time that, after imatinib treatment, an additional specific and novel ...
BACKGROUND Dynamic hyperinflation, caused by expiratory flow limitation, markedly increases resting end-expiratory lung volume (functional residual capacity) in many COPD patients. OBJECTIVE To determine the impact and duration of impact of CPAP on hyperinflation and airway resistance in patients with stable COPD. METHODS In a case series, 21 patients underwent CPAP at 8 cm H(2)O for 15 min...
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