The aim of the study is to determine and compare the pharmacokinetics and tissue distribution of Doxorubicin (Dox) delivered as solution or through nanoparticles after intravenous (i.v.) and intraperitoneal (i.p.) injection. Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles were synthesized by dispersion polymerization (DP) and emulsion polymerization (EP) techniques. The drug loaded D...

We have studied dose requirements, recovery times and pharmacokinetics of rocuronium in 32 intensive care patients. After an initial dose of 50 mg, rocuronium was administered as maintenance doses of 25 mg whenever two responses to train-of-four (TOF) stimulation reappeared (bolus group; n = 27) or by continuous infusion to maintain one response in the TOF (infusion group; n = 5). Median requir...

The behaviour of passive tracer particles in capillary Poiseuille flow is investigated with regard to the residence time in short axial sections of length z , in which z /a < Va/D, where a is the capillary radius, V is the mean velocity and D the coefficient of molecular diffusion. While methods exist for calculating moments of the crosssectionally averaged axial concentration distribution as a...

In this paper a two impinging streams cyclone contacting system suitable for handling of solid-liquid systems has been studied. Certain pertinent parameters such as: solid holdup, mean residence time and Residence Time Distribution (RTD) of solid particles have been investigated. A stochastic model based on Markov chains processes has been applied which describe the behavior of solid partic...

This project involved the study of Brownian motion of polystyrene microspheres in the presence of gravity and a one-dimensional sinusoidal optical potential generated by the interference of two laser beams. An exponential relationship was observed between applied laser power and particle residence time of individual interference fringes. Increasing laser power also revealed a wider distribution...

in this article, a complete model for the mixed flow slurry reactor for polymerization of ethylene to high density polyethylene in the presence of ziegler-natta catalyst is presented. in addition to the effects of the multiple active sites, the effect of other important parameters such as the catalyst concentration, co-catalyst, hydrogen, monomer, impurities and pressure on the mass-average and...